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FLASH GENE
Symbol CA14 contributors: - updated : 02-12-2004
HGNC name carbonic anhydrase XIV
HGNC id 1372
Location 1q21      Physical location : 150.230.217 - 150.237.476
EC.number 4.2.1.1.
DNA
TYPE functioning gene
STRUCTURE 7.00 kb     11 Exon(s)
Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status provisional
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
Digestiveliver    
Nervousbrain    
Urinarykidney    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal  
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
a N terminal signal sequence,two cysteine residues in the CA extracellular domain and a C terminal transmembrane segment
conjugated MetalloP
isoforms Precursor
HOMOLOGY
intraspecies homolog to CA12,highly
Homologene
FAMILY eukaryotic-type carbonic anhydrase family
CATEGORY enzyme
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,cytosolic
basic FUNCTION
  • carbonic anhydrase 14. reversibly hydrating Co2 in cellular ion transport and pH homeostasis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS homeostasis
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
    zinc Zn2+
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS