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FLASH GENE
Symbol CA11 contributors: mct/npt - updated : 16-07-2008
HGNC name carbonic anhydrase XI
HGNC id 1370
Location 19q13.3      Physical location : 49.141.271 - 49.149.451
Synonym name
  • carbonic anhydrase-related protein 2
  • carbonic anhydrase-related protein XI
  • carbonic anhydrase-related protein 2
  • Synonym symbol(s) CARP2, D19S799E, CARPX1, CA-XI
    EC.number 2.4.1.1
    DNA
    TYPE functioning gene
    SPECIAL FEATURE
    text embedded between the secretor cluster and DBP
    STRUCTURE 8.18 kb     9 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Map see FUT1
    Physical map
    CARD8 19q13.33 caspase recruitment domain family, member 8 MGC17986 19q13.33 hypothetical protein MGC17986 FLJ32926 19q13.33 hypothetical protein FLJ32926 EMP3 19q13.3 epithelial membrane protein 3 FLJ10922 19q13.33 hypothetical protein FLJ10922 SYNGR4 19q13.3 synaptogyrin 4 KDELR1 19q13.2-q13.3 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1 GRIN2D 19q13.1-qter glutamate receptor, ionotropic, N-methyl D-aspartate 2D GRWD1 19q13.33 glutamate-rich WD repeat containing 1 KCNJ14 19q13 potassium inwardly-rectifying channel, subfamily J, member 14 PSCD2 19q13.3 pleckstrin homology, Sec7 and coiled-coil domains 2 (cytohesin-2) KIAA1883 SULT2B1 19q13.3 sulfotransferase family, cytosolic, 2B, member 1 FLJ20200 19q13.33 hypothetical protein FLJ20200 SPACA4 19q13.3-14 sperm acrosome associated 4 RPL18 19q13.3 ribosomal protein L18 SPHK2 19q13.2 sphingosine kinase 2 DBP 19q13.3 D site of albumin promoter (albumin D-box) binding protein CA11 19q13.3 carbonic anhydrase XI LOC126147 19q13.33 hypothetical protein BC018697 FUT2 19q13.3 fucosyltransferase 2 (secretor status included) FLJ36070 19q13.33 hypothetical protein FLJ36070 RAIN 19q13.33 Ras-interacting protein MGC34799 19q13.33 hypothetical protein MGC34799 FUT1 19q13.3 fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, Bombay phenotype included) FGF21 19q13.1-qter fibroblast growth factor 21 BCAT2 19q13.3 branched chain aminotransferase 2, mitochondrial DHRS10 19q13.33 dehydrogenase/reductase (SDR family) member 10 PLEKHA4 19q13.33 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4 PPP1R15A 19q13.2 protein phosphatase 1, regulatory (inhibitor) subunit 15A TULP2 19q13.1 tubby like protein 2 NUCB1 19q13.32 nucleobindin 1 DHDH 19q13.3 dihydrodiol dehydrogenase (dimeric) BAX 19q13.3-q13.4 BCL2-associated X protein FTL 19q13.3 ferritin, light polypeptide GYS1 19q13.3 glycogen synthase 1 (muscle) RUVBL2 19q13.3 RuvB-like 2 (E. coli)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    9 - 1686 36.2 328 - Yang (2008)
    EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrineneuroendocrinepituitary  highly
    Nervousbrainforebraincerebral cortex highly
     brainhindbraincerebellum moderately
    nervousbrainbasal nucleiputamen  
    Nervousnerve   highly
     spinal cord   moderately
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialsecretoryglandularendocrine 
    Nervouscentral   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Nervousastrocyte
    Nervousneuron
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period embryo
    Text neuroprogenitor cells in the subventricular zone as early as the 84th day of gestation and subsequently detected in the neural cells migrating to the cortex
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • missing the three His essential for catalytic activity
  • a sequence homologous to the frog neuropeptide sauvagine
  • conjugated MetalloP
    isoforms Precursor
    HOMOLOGY
    intraspecies homolog to acatalytic carbonic anhydrase peptide VIII and X
    Homologene
    FAMILY
  • alpha-carbonic anhydrase family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • E3 ligases that target TP53 as well as phospho-TP53 for degradation
  • play roles in various biological process of the CNS
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Zn2+
  • protein
  • target SFN for degradation, leading to MDM2 stabilization
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    enhancing MDM2/MDMX interaction
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS