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FLASH GENE
Symbol CA1 contributors: mct - updated : 27-04-2018
HGNC name carbonic anhydrase I
HGNC id 1368
Location 8q21.2      Physical location : 86.240.457 - 86.290.342
Synonym name
  • carbonic dehydratase
  • carbonic anhydrase B
  • Synonym symbol(s) CAH1, CAR1, CAB
    EC.number 4.2.1.1
    DNA
    TYPE functioning gene
    STRUCTURE 49.94 kb     9 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    Physical map
    LOC392241 8 similar to tropomyosin 3, gamma LOC138046 8q21.13 hypothetical protein LOC138046 KIAA1764 8q21.13-q21.2 KIAA1764 protein E2F5 8q21.13 E2F transcription factor 5, p130-binding MGC59868 CA1 8q13-q22.1 carbonic anhydrase I CA3 8q13-q22.1 carbonic anhydrase III, muscle specific CA2 8q13-q22.1 carbonic anhydrase II LOC392242 8 hypothetical gene supported by NM_172239 GOR 8q21.2 exonuclease GOR LOC392243 8 hypothetical gene supported by NM_172239 LOC392244 8 hypothetical gene supported by NM_172239 LOC392245 8 hypothetical gene supported by NM_172239 LOC392246 8 hypothetical gene supported by NM_172239 LOC392247 8 hypothetical gene supported by NM_172239 LOC392248 8 similar to large subunit ribosomal protein L36a LOC392249 8 similar to 60S ribosomal protein L32 PSKH2 8q21.2 serine/threonine kinase PSKH2 ATP6V0D2 8q21.13 ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d isoform 2 SLC7A13 8q21.2 solute carrier family 7, (cationic amino acid transporter, y  system) member 13 WWP1 8q21 solute carrier family 7, (cationic amino acid transporter, y  system) member 13 CGI-90 8q21.2 CGI-90 protein CPNE3 8q22.1-q22.2 copine III CNGB3 8q21-q22 cyclic nucleotide gated channel beta 3
    RNA
    TRANSCRIPTS type messenger
    text all variants encode the same protein
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    9 - 1278 28.74 261 - Gambhir (2007)
    - - 1224 28.74 261 - -
    - - 1301 28.74 261 - -
    9 - 1299 28.74 261 - -
    9 - 1211 - 261 - -
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestine    
     stomach    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoieticbone marrow   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticerthrocyte
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    conjugated MetalloP
    isoforms Precursor
    HOMOLOGY
    interspecies homolog to car1
    Homologene
    FAMILY
  • alpha-carbonic anhydrase family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • appear to be good markers for the differentiation of enterocytes in the colonic mucosa
  • reversibly hydrating Co2 in cellular ion transport and Ph homeostasis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Zn2+
  • protein
  • LDB1 forms a regulatory complex to maintain CA1 expression in erythroid cells
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    in erythrocytes of type II diabetic patients
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS