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FLASH GENE
Symbol C9orf89 contributors: - updated : 28-04-2006
HGNC name chromosome 9 open reading frame 89
HGNC id 0
Location 9q22.31      Physical location : 95.858.449 - 95.875.564
Synonym symbol(s) BinCARD
DNA
TYPE functioning gene
STRUCTURE 17.00 kb     4 Exon(s)
MAPPING cloned Y linked   status provisional
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type ubiquitous
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrineadrenal gland   moderately
 parathyroid   predominantly
Lymphoid/Immunespleen   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectivebone   
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a CARD domain
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    text
  • co-expression with BCL10 induced translocation from nucleus to
  • cytosol
    basic FUNCTION
  • playing a role in inhibiting the effects of BCL10-induced activation of NF-kappa-B
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    negative regulation of I-kappaB kinase/NF-kappaB cascade
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • BCL10 by CARD-CARD interaction
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS