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FLASH GENE
Symbol C5AR1 contributors: npt/ - updated : 02-03-2006
HGNC name complement component 5a receptor 1
HGNC id 1338
Location 19q13.32      Physical location : 47.813.103 - 47.825.327
Synonym name
  • C5a anaphylatoxin chemotactic receptor
  • complement component 5 receptor 1 (C5a ligand)
  • CD88 antigen
  • Synonym symbol(s) C5AR, CD88, C5A, C5R1
    DNA
    TYPE functioning gene
    STRUCTURE 12.22 kb     2 Exon(s)
    MAPPING cloned Y linked   status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    2 - 2342 - 350 - -
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Respiratorylung    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoietic    
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticeosinophil
    cell lineage
    cell lines
    fluid/secretion blood
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • seven transmembrane segments (7TM) receptor, forming seven helices
  • conjugated GlycoP
    HOMOLOGY
    interspecies ortholog to murine C5r1
    Homologene
    FAMILY
  • G protein coupled receptor 1 family
  • CATEGORY immunity/defense , receptor
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • C5A (anaphylatoxin) receptor
  • stimulating chemotoxics, granule enzyme release and superoxide anion and participating in the defense of choroidal and retinal tissues during inflammation
  • CELLULAR PROCESS cell communication
    PHYSIOLOGICAL PROCESS immunity/defense
    text communication motility increasing polarization and migration
  • required formucosal bacterial defense in the lung
  • PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • enhancing C5a-mediated release of IL8 upon exposure to cigarette smoke
  • interacting with RGS3 (in apoptosis-initiated cells, the ligand-dependent C5AR1-mediated dual signal affects the fate of cells, either apoptosis execution or survival, through regulation of RGS3 gene expression and subsequent modulation of ERK signal (Nishiura 2009)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene in antiphospholipid syndrome (MIM107320)(Gilardi(03))
    Marker
    Therapy target
    ANIMAL & CELL MODELS