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FLASH GENE
Symbol C3AR1 contributors: mct - updated : 08-09-2014
HGNC name complement component 3a receptor 1
HGNC id 1319
Location 12p13.31      Physical location : 8.210.918 - 8.218.955
Synonym name
  • C3a anaphylatoxin chemotactic receptor
  • Synonym symbol(s) AZ3B, C3AR, HNFAG09, EVI146
    DNA
    TYPE functioning gene
    STRUCTURE 8.04 kb     2 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status provisional
    Map pter - D12S99 - SLC9A1 - GAPDH - DRPLA - PTMS - GNB3 - PEX5 - POLR2C - D12S358 - D12S77 - C3AR1 - CD69 - cen
    Authors GeneMap98
    Physical map
    C2F 12p13 C2f protein LOC390285 12 similar to vav-1 interacting Kruppel-like protein isoform b C1S 12p13.31 complement component 1, s subcomponent C1R 12p13.31 complement component 1, r subcomponent C1RL 12p13.31 complement component 1, r subcomponent-like LOC283314 12p13.31 hypothetical protein LOC283314 RBP5 12p13.2 retinol binding protein 5, cellular CLSTN3 12p13.31 calsyntenin 3 PXR1 12p13.31 peroxisome receptor 1 LOC341392 12p13.31 similar to olfactory specific medium-chain acyl CoA synthetase M160 12p13.31 scavenger receptor cysteine-rich type 1 protein M160 CD163 12p13.3 CD163 antigen LOC390286 12 similar to Glyceraldehyde 3-phosphate dehydrogenase, liver (GAPDH) APOBEC1 12p13.2-p13.1 apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1 GDF3 12p13.1 growth differentiation factor 3 LOC338759 12p13.31 STELLA CLECSF11 12p13.2-p12.3 C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamily member 11 LOC360030 12p13.31 homeobox C14 NANOG 12p13.31 Nanog homeobox SLC2A14 12p13.3 solute carrier family 2 (facilitated glucose transporter), member 14 SLC2A3 12p13.3 solute carrier family 2 (facilitated glucose transporter), member 3 LOC283320 12p13.31 similar to 60 kDa heat shock protein, mitochondrial precursor (Hsp60) (60 kDa chaperonin) (CPN60) (Heat shock protein 60) (HSP-60) (Mitochondrial matrix protein P1) (P60 lymphocyte protein) (HuCHA60) FHX 12pter-p13.31 similar to 60 kDa heat shock protein, mitochondrial precursor (Hsp60) (60 kDa chaperonin) (CPN60) (Heat shock protein 60) (HSP-60) (Mitochondrial matrix protein P1) (P60 lymphocyte protein) (HuCHA60) C3AR1 12p13.3-p13.1 complement component 3a receptor 1 DKFZP566B183 12p13.31 DKFZP566B183 protein CLECSF6 12p13.1 C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamily member 6 LOC283321 12p13.31 hypothetical LOC283321 LOC387828 12 LOC387828 FLJ10408 12p13.31 hypothetical protein FLJ10408 LOC387829 12 similar to Asparagine-linked glycosylation 1 homolog (yeast, beta-1,4-mannosyltransferase) LOC387830 12 similar to CG7889-PA LOC93320 12p13.31 similar to Alkaline sphingomyelinase LOC387831 12 hypothetical gene supported by AK074886 LOC390287 12 hypothetical gene supported by AK122996 LOC390288 12 similar to olfactory receptor GA_x6K02T2PVTD-14054886-14053957 LOC390289 12 similar to seven transmembrane helix receptor LOC341306 12p13.31 similar to 60S ribosomal protein L15 CLECSF8 12p13.31 C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamily member 8 CLECSF9 12p13.32 C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamily member 9 AICDA 12p13 activation-induced cytidine deaminase LOC94468 12p13.31 similar to 78 kDa gastrin-binding protein MAGP2 12p13.1-p12.2 similar to 78 kDa gastrin-binding protein KIAA1238 12p13.31 similar to 78 kDa gastrin-binding protein FLJ25179 12p13.31 hypothetical protein FLJ25179 PHC1 12p13 polyhomeotic-like 1 (Drosophila) M6PR 12p13.2 mannose-6-phosphate receptor (cation dependent) KLRG1 12p13.2-p13.1 killer cell lectin-like receptor subfamily G, member 1 LOC390290 12 similar to Heterogeneous nuclear ribonucleoprotein A1 (Helix-destabilizing protein) (Single-strand binding protein) (hnRNP core protein A1) (HDP) LOC390291 12 similar to voltage-dependent anion channel isoform 2 MGC40170 12p13.31 hypothetical protein MGC40170 A2M 12p13.2-p13.1 alpha-2-macroglobulin PZP 12p13.2-p13.1 pregnancy-zone protein
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    2 - 1985 - 482 - 1998 9710219
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    blood / hematopoieticspleen    
    Cardiovascularheart    
    Digestiveintestinesmall intestine   
    Reproductivefemale systemovary   
    Respiratorylung    
    Urinarykidneytubuleconvoluted tubule highly Homo sapiens
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectiveadiposewhite highly Homo sapiens
    Nervouscentral   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Urinaryepithelial cell Homo sapiens
    cell lineage differentiated hematopoietic cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • two extracellular loop
  • seven hydrophobic membrane spenning helices and large secund extracellular loop (172AA) between the fourth and the fifth transmembrane domain
  • ten potential phosphorylation sites within its C-terminus
  • HOMOLOGY
    interspecies homolog to murine C3AR1
    intraspecies homolog to C5A receptor
    Homologene
    FAMILY family 1 of G protein coupled receptor
    CATEGORY receptor
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • C3AR1 activation-induced depression of cAMP was associated with enhanced capacity of dendritic cells (DCs) for antigen uptake and T-cell stimulation
  • C3AR1 in macrophages, and potentially adipocytes, plays an important role in adipose tissue homeostasis and insulin resistance
  • its phosphorylation at multiple sites mediates desensitization, ARRB2 recruitment and inhibition of NFKB1 activity in mast cells
  • specific role for C3AR1 in constraining neutrophil mobilization in response to intestinal injury
  • C3AR1 and CD46 activation via intrinsic generation of their respective ligands is an integral part of human Th1 (but not Th2) immunity
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS inflammation
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • ADRBK1, ADRBK2 are involved in C3AR1 desensitization
  • GRK5 and GRK6 promote C3A-induced mast cell degranulation but inhibit ERK1/2 phosphorylation via C3AR1 desensitization-independent mechanisms
  • roles for SLC9A3R1 and SLC9A3R2 on the regulation of C3AR1 signaling in human mast cells
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    of C3aR mRNA and protein expression in placentas with preeclampsia compared to controls
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • C3aR(-/-) mice also mobilized more circulating neutrophils after granulocyte colony-stimulating factor infusion compared with WT mice