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FLASH GENE
Symbol C1QTNF6 contributors: mct - updated : 08-03-2010
HGNC name C1q and tumor necrosis factor related protein 6
HGNC id 14343
Location 22q12.3      Physical location : 37.576.205 - 37.584.330
Synonym name complement-c1q tumor necrosis factor-related protein 6
Synonym symbol(s) CTRP6, ZACRP6
DNA
TYPE functioning gene
STRUCTURE 8.31 kb     3 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
RABL4 22q13.1 RAB, member of RAS oncogene family-like 4 PVALB 22q13.1 parvalbumin NCF4 22q13.1 neutrophil cytosolic factor 4, 40kDa CSF2RB 22q13.1 colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage) CSF2RB2 22q13.1 colony stimulating factor 2 receptor, beta, 2 MGC35206 22q13.1 hypothetical protein MGC35206 TST 22q13.1 thiosulfate sulfurtransferase (rhodanese) MPST 22q13.1 mercaptopyruvate sulfurtransferase FLJ12242 22q13.1 hypothetical protein FLJ12242 TMPRSS6 22q13.1 transmembrane serine protease 6 IL2RB 22q13.1 interleukin 2 receptor, beta C1QTNF6 22q13.1 C1q and tumor necrosis factor related protein 6 SSTR3 22q13.1 somatostatin receptor 3 RAC2 22q13.1 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) PSCD4 22q13.1 pleckstrin homology, Sec7 and coiled-coil domains 4 KIAA1904 22q13.1 KIAA1904 protein MFNG 22q13.1 manic fringe homolog (Drosophila) CARD10 22q13 caspase recruitment domain family, member 10 CDC42EP1 22q13.1 CDC42 effector protein (Rho GTPase binding) 1 LGALS2 22q13.1 lectin, galactoside-binding, soluble, 2 (galectin 2) GGA1 22q13.31 golgi associated, gamma adaptin ear containing, ARF binding protein 1 SH3BP1 22q13.1 SH3-domain binding protein 1 PLP
regionally located close (hiting) IL2RB (NCBI annotation project)
RNA
TRANSCRIPTS type messenger
text ten alternatively transcribed transcripts altogether encoding eight proteins
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
3 - 2954 - 278 - 2003 12975309
4 - 1670 - 278 - 2003 12975309
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrain    
Reproductivefemale systemplacenta  predominantly Homo sapiens
Visualeye   predominantly Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period pregnancy
Text placenta
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • one C1q domain
  • one collagen-like domain
  • conjugated GlycoP
    HOMOLOGY
    Homologene
    FAMILY
  • C1q/TNF family
  • CATEGORY immunity/defense , regulatory
    SUBCELLULAR LOCALIZATION extracellular
    text secreted
    basic FUNCTION
  • circulate in the blood and is potential endocrine hormone
  • mediates the phosphorylation and activation of the 5'-AMP-activated protein kinase in skeletal muscle cells
  • inducing the phosphorylation of acetyl coenzyme A carboxylase and fatty acid oxydation in myocytes
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS immunity/defense
    text immune response
    PATHWAY
    metabolism
    signaling signal transduction
    fatty acid metabolism via the AMPK-ACC pathway
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS