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FLASH GENE
Symbol C1QTNF3 contributors: mct/npt/pgu - updated : 09-11-2009
HGNC name C1q and tumor necrosis factor related protein 3
HGNC id 14326
Location 5p13.3      Physical location : 34.017.963 - 34.043.317
Synonym name
  • cartducin
  • collagenous repeat-containing sequence of 26-kDa
  • cartonectin
  • complement-c1q tumor necrosis factor-related protein 3
    • Synonym symbol(s) CTRP3, CORS26, CORS-26, C1ATNF3, Cors, Corcs, 2310005P21Rik, FLJ37576
    EC.number 5.1.99.4
    DNA
    TYPE functioning gene
    STRUCTURE 25.36 kb     6 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    motif
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    6 splicing 3570 26 246 - 2010 20952387
  • CTRP3A
  • protein sequence is highly conserved throughout vertebrate evolution, with amino acid identity ranging from 78 to 99p100
  • CTRP3A interacted with CTRP3B only when they were co-expressed in the same cell
    • 6 splicing 3789 - 319 - 2010 20952387
  • no collagen domain
  • CTRP3B having a larger exon 1 due to the retention of 219 nucleotides from the intron 1 sequence
  • an extra 73 AAs in the N terminus, which contains a highly conserved N-linked glycosylation site
  • CTRP3A interacted with CTRP3B only when they were co-expressed in the same cell
    		•
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinelarge intestinecolon   Homo sapiens
     intestinesmall intestine  highly Homo sapiens
    Endocrinepancreas   highly Homo sapiens
    Lymphoid/Immunethymus   moderately Homo sapiens
    Nervousbrain   moderately Homo sapiens
    Reproductivefemale systemovary  moderately Homo sapiens
    Urinarykidney   moderately Homo sapiens
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectiveadipose  predominantly Homo sapiens
    Connectivecartilage   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticmonocyte
    Lymphoid/Immunedendritic cell
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period embryo
    Text prechondrocytic cell of cartilage
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a collagen triple helix repeat (Gly-X-Y repeats) at the N terminus
  • a complement factor C1q globular domain at the C terminus
    • HOMOLOGY
    interspecies ortholog to murine Cors26
    intraspecies homolog to ACRP30
    Homologene
    FAMILY
  • C1q/TNF-alpha molecular superfamily
    • CATEGORY enzyme , immunity/defense
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • adipocytokine that may play an important role in skeletal development
  • exerts anti-inflammatory properties and is expressed in monocytic cells
  • acting as a regulator of angiogenic processes, and may be involved as a novel angiogenic factor in the formation of neointima following angioplasty
  • new adipokine that differentially regulates the secretion of classical adipokines, with marked differences between the human and the murine systems (basal adipokine secretion is influenced by the BMI)
  • circulate in the blood and is potential endocrine hormone
  • is linked to hepatic glucose metabolism and a novel adipokine
  • stimulates chondrogenic precursor cell proliferation and promotes angiogenesis
  • metabolic regulator of glucose homeostasis
  • acts directly on liver cells, independent of insulin, to suppress gluconeogenic gene expression and glucose production
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS development
    text skeletal development
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS