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FLASH GENE
Symbol C1QTNF12 contributors: mct - updated : 20-02-2018
HGNC name C1q and TNF related 12
HGNC id 32308
Location 1p36.33      Physical location : -
Synonym name
  • C1q domain containing 2
  • adipolin (adipose-derived insulin-sensitizing factor)
  • C1q/TNF-related protein 12
  • family with sequence similarity 132, member A
  • Synonym symbol(s) C1QDC2, MGC105127, FAM132A, CTRP12
    DNA
    TYPE functioning gene
    STRUCTURE 4.28 kb     8 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    8 - 1055 32 302 - 2012 21849507
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrineadrenal gland    
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectiveadiposewhite highly Homo sapiens
    Connectiveadiposebrown highly Homo sapiens
    cells
    SystemCellPubmedSpeciesStageRna symbol
    not specificadipocyte Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    HOMOLOGY
    Homologene
    FAMILY
  • FAM132 family, CTRP family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • insulin-sensitizing adipokine, functioning as an anti-inflammatory adipokine that exerts beneficial actions on glucose metabolism
  • adipokine with anti-diabetic actions
  • directly activated the PI3K-AKT1 signaling pathway to suppress gluconeogenesis and promote glucose uptake, respectively
  • novel metabolic regulator linking adipose tissue to whole body glucose homeostasis through insulin-dependent and independent mechanisms
  • insulin-sensitizing adipokine that regulates glucose metabolism in liver and adipose tissue
  • is an insulin-sensitizing and anti-inflammatory adipokine
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • PCSK3/furin was identified as the major proprotein convertase expressed by adipocytes that mediates the endogenous cleavage of C1QTNF12
  • is an adipocytokine that exerts beneficial actions on glucose metabolism
  • transcriptional regulator Krüppel-like factor (KLF15) is involved in the regulation of C1QTNF12 expression in adipocytes
  • hyperinsulinaemic induction in healthy lean human subjects significantly increased circulating levels of C1QTNF12
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    diabete  
    new target molecule for the treatment of insulin resistance and diabetes
    ANIMAL & CELL MODELS
  • increasing adipolin expression ameliorates adipose tissue inflammation and promotes glucose clearance in obese mice
  • diet-induced obese (DIO) mice showed a significant reduction of plasma levels of full and total (full and cleaved) adipolin compared with control mice, resulting in an increase in the ratio of cleaved to full isoform
  • in mice, loss of a single Ctrp12 allele affects glucose and lipid metabolism in a sex-dependent manner