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FLASH GENE
Symbol C1QTNF1 contributors: mct - updated : 17-11-2010
HGNC name C1q and tumor necrosis factor related protein 1
HGNC id 14324
Location 17q25.3      Physical location : 77.020.250 - 77.045.869
Synonym name
  • G protein coupled receptor interacting protein
  • complement C1q tumor necrosis factor-related protein 1
  • Synonym symbol(s) GIP, CTRP1, ZSIG37, FLJ90694
    DNA
    TYPE functioning gene
    STRUCTURE 26.96 kb     4 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    4 - 2923 - 281 - 2008 18783346
    4 - 2704 - 281 - 2008 18783346
    3 - 2744 - 199 - 2008 18783346
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Endocrineadrenal glandcortexzona glomerula highly Homo sapiens
    Nervousbrain    
    Reproductivemale systemprostate   
    Respiratorylung    
    Skin/Tegumentskin    
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectiveadipose  predominantly Homo sapiens
    Muscularstriatumcardiac  
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a N terminal collagen, triple helix repeat (Gly-X-Y repeats), and a signal peptide sequence followed by a variable region
  • a collagen repeat domain
  • a complement, C1q globular domain at the C terminus factor
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY immunity/defense , regulatory
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • its expression may be associated with a low-grade chronic inflammation status in adipose tissues
  • increasing aldosterone production in cells of the adrenal cortex
  • circulate in the blood and is potential endocrine hormone
  • may be considered a novel adipokine
  • may have partially overlapping functions and, along with other paralogues, may effectively compensate for the chronic loss of adiponectin function
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    induced by proinflammatory cytokines, including TNF1 and IL1B
    PPARgamma (peroxisome-proliferator-activated receptor gamma) agonists
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    in obese subjects
    constitutional       gain of function
    in hypertensive patients
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS