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FLASH GENE
Symbol C1QL4 contributors: mct - updated : 28-03-2022
HGNC name complement component 1, q subcomponent-like 4
HGNC id 31416
Location 12q13.12      Physical location : 49.726.199 - 49.730.971
Synonym name
  • C1q and tumor necrosis factor-related protein 11
    • Synonym symbol(s) C1QTNF11, CTRP11, MGC131708
    DNA
    TYPE functioning gene
    STRUCTURE 4.79 kb     2 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    2 - 2073 - 238 - 2019 30608882
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrain     Homo sapiens
    Reproductivefemale systemovary   
     female systemuterus   
     male systemtestis    Homo sapiens
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectiveadipose    Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    		a C1Q domain
    HOMOLOGY
    Homologene
    FAMILY C1q/TNF family
    CATEGORY unknown/unspecified
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    basic FUNCTION
  • C1QL1, C1QL2, C1QL3, C1QL4 proteins are secreted signaling molecules that bind to ADGRB3 and act, at least in part, to regulate synapse formation and/or maintenance
  • CQL1/Ctrp14 and C1QL4/Ctrp11 stimulate the new blood vessel growth by activation of ERK1/2 signal pathway
  • C1QL4 served as a novel acute regulator of testosterone secretion, and ADGRB3 functioned as a new receptor that is involved in steroidogenesis in Leydig cells
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • ADGRB3 is spatiotemporally regulated by C1QL4 and STAB2 during myoblast fusion
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS