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FLASH GENE
Symbol C1QL3 contributors: mct - updated : 19-12-2011
HGNC name complement component 1, q subcomponent-like 3
HGNC id 19359
Location 10p13      Physical location : 16.555.741 - 16.564.004
Synonym name gliacolin 1
Synonym symbol(s) C1ql, K100, C1QTNF13, CTRP13
DNA
TYPE functioning gene
STRUCTURE 8.26 kb     2 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
2 - 2493 - 255 - 2005 15953544
EXPRESSION
Rna function
  • C1QL2 and C1Ql3 mRNAs were potentially strongly coexpressed in the dentate gyrus
  • Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Lymphoid/Immunelymph node    
    Nervousbrain   lowly Homo sapiens
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectiveadipose  predominantly Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period embryo
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a signal peptide, a short N terminus with two highly conserved Cys residues, a collagen domain with 17 Gly-X-Y repeats
  • a signature C-terminal globular domain homologous to the immune complement C1q and whose three-dimensional structures strikingly resemble that of TNF
  • HOMOLOGY
    Homologene
    FAMILY C1q/TNF family
    CATEGORY unknown/unspecified
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • may play diverse roles by forming homomeric and heteromeric complexes in the central nervous system
  • adipokine that promotes glucose uptake in adipocytes, myotubes, and hepatocytes via activation of the AMPK signaling pathway
  • also ameliorates lipid-induced insulin resistance in hepatocytes through suppression of the SAPK/JNK stress signaling that impairs the insulin signaling pathway
  • important role in glucose homeostasis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • forms heteromeric complexes with a closely related family member, C1QL2
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS