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FLASH GENE

Symbol

C1QC

contributors: mct/npt - updated : 21-09-2009

HGNC name	complement component 1, q subcomponent, C chain
HGNC id	1245

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	1p36.12      Physical location : 22.970.117 - 22.974.602
Synonym name	complement component 1, q subcomponent, gamma polypeptide
Synonym symbol(s)	C1QG, C1q-C, FLJ27103

DNA

TYPE	functioning gene
SPECIAL FEATURE	component of a cluster
STRUCTURE	4.49 kb     3 Exon(s)

MAPPING

cloned

Y

linked

N

status

confirmed

regionally located

clustered with C1QA, C1QB in the order A, C, B

RNA

TRANSCRIPTS	type	messenger

text	variants 1 and 2 encode the same protein

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed variant 1 NM_001114101 3 - 1205 isoform 1 22.8 245 - Sellar (1991) variant 2 NM_172369 3 - 1182 isoform 1 22.8 245 - Sellar (1991)

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Lymphoid/Immune spleen       highly   thymus       highly

cell lineage
cell lines
fluid/secretion	serum

at STAGE

physiological period

pregnancy

Text

placenta

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a globular head
	a collagen-like domain
	a C terminal carbohydrate binding domain, assembling as trimers which form oligomers
	a C1Q domain

conjugated

GlycoP

mono polymer

monomer

HOMOLOGY

interspecies

ortholog to murine C1qg

intraspecies

homolog to collagen-like sequence of COL VIII and COLX

Homologene

FAMILY

CATEGORY

immunity/defense , secretory

SUBCELLULAR LOCALIZATION

extracellular

basic FUNCTION	complement component 1
	q subcomponent
	classical pathway of C3 activation
	induces maturation of human dendritic cells (Csomor 2007)

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

AGER is a native C1QA, C1QB, C1QC globular domain receptor (C1q and AGER are linked to the recruitment of leukocytes and phagocytosis of C1q-coated material)

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS