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FLASH GENE
Symbol C1QB contributors: mct/npt - updated : 21-09-2009
HGNC name complement component 1, q subcomponent, B chain
HGNC id 1242
Corresponding disease
C1QB complement component 1QB deficiency
Location 1p36.12      Physical location : 22.979.681 - 22.988.028
Synonym name
  • complement component 1, q subcomponent, beta polypeptide
  • complement component C1q, B chain
    • DNA
    TYPE functioning gene
    SPECIAL FEATURE component of a cluster
    STRUCTURE 8.35 kb     3 Exon(s)
    Genomic sequence alignment details
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    Text see C1Q@
    regionally located clustered with C1QA, C1QG in the order 5' - A, C(G), B - 3'
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    3 - 1044 26.6 253 - Marquart (2007)
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivestomach   highly
    Endocrineadrenal gland   highly
    Lymphoid/Immunespleen   highly
    cell lineage
    cell lines
    fluid/secretion serum
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a globular head,
  • a collagen-like domain
  • a C terminal carbohydrate binding domain, forming a disulfide-linked dimer with C1QA
  • a C1Q-domain
    • mono polymer monomer
    HOMOLOGY
    intraspecies homolog to non collagen-like sequence of COLVIII and COLX
    Homologene
    FAMILY
    CATEGORY immunity/defense
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • classical pathway of C3 activation
  • induces maturation of human dendritic cells (Csomor 2007)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • forming a disulfide linked dimer with a C1QA
  • part of the C1 complex including six C1QA, six C1QB, six C1QG
    • INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Ca2+
    • protein
  • AGER is a native C1QA, C1QB, C1QC globular domain receptor (C1q and AGER are linked to the recruitment of leukocytes and phagocytosis of C1q-coated material)
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) C1QB
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS