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FLASH GENE
Symbol C1D contributors: mct - updated : 23-08-2013
Location 2p14      Physical location : 68.269.332 - 68.290.159
Genatlas name nuclear DNA-binding protein
Synonym name
  • small unique nuclear receptor corepressor
  • C1D DNA-binding protein
  • nuclear DNA-binding protein, isoform CRA_a
  • Synonym symbol(s) SUNCOR, MGC12261 , MGC14659, LRP1, SUN-CoR, hC1D
    DNA
    TYPE functioning gene
    STRUCTURE 20.82 kb     5 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Promoter
    motif repetitive sequence
    text structure LINE-1 element in the promoter controling the expression of nearby genes
    MAPPING cloned Y linked N status provisional
    Physical map
    MEIS1 2p14-p13 Meis1, myeloid ecotropic viral integration site 1 homolog (mouse) LOC391381 2 similar to DNA cytosine methyltransferase 3 alpha isoform a; DNA methyltransferase HsaIIIA; DNA MTase HsaIIIA; DNA cytosine methyltransferase 3A2 ETAA16 2p13-p15 ETAA16 protein LOC391382 2 similar to F-box/LRR-repeat protein 12 (F-box and leucine-rich repeat protein 12) C1D 2p13-p12 similar to F-box/LRR-repeat protein 12 (F-box and leucine-rich repeat protein 12) LOC116143 2p13.3 hypothetical protein BC014022 LOC56902 2p13.3 putatative 28 kDa protein PPP3R1 2p16-p15 protein phosphatase 3 (formerly 2B), regulatory subunit B, 19kDa, alpha isoform (calcineurin B, type I) DKFZP566K1924 2p13.3 DKFZP566K1924 protein PLEK 2p14 pleckstrin LOC391383 2 similar to WD repeat domain 4 protein; WD repeat-containing protein 4 MGC47799 LOC391384 2 similar to KIAA0779 protein GPR73 2p14-p13.1 G protein-coupled receptor 73 KIAA0053 2p13.3 G protein-coupled receptor 73 BMP10 2p13.3 bone morphogenetic protein 10 LOC391385 2 similar to 18 kDa antrum mucosa protein; BRICHOS domain containing 1 GDDR 2p13.3 down-regulated in gastric cancer GDDR GKN1 2p13.3 gastrokine 1 ANTXR1 2p13.1 anthrax toxin receptor 1 GFPT1 2p13 glutamine-fructose-6-phosphate transaminase 1 HIRIP5 2p12 HIRA interacting protein 5 LOC388957 2 similar to expressed sequence C79663 LOC388958 2 hypothetical gene supported by AF090101 AAK1 2p24.3-p14 AP2 associated kinase 1 ANXA4 2p13 annexin A4 FLJ13057 2p13.3 hypothetical protein FLJ13057 similar to germ cell-less RY1 2p13.3 putative nucleic acid binding protein RY-1 MAD 2p12 MAX dimerization protein 1 FLJ25084 2p13.3 hypothetical protein FLJ25084 PCBP1 2p13-p12 poly(rC) binding protein 1 LOC151518 2p13.3 hypothetical LOC151518
    RNA
    TRANSCRIPTS type messenger
    text Variants 1 and 2 encode the same isoform
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    5 - 1207 16 141 - Schilders (2007)
    5 - 1194 16 141 - Schilders (2007)
    6 - 1281 - 141 - -
    6 - 1294 - 141 - -
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivesalivary gland   highly
    Urinarybladder   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • nuclear localization signal (NLS)
  • HOMOLOGY
    interspecies homolog to murine Suncor
    Homologene
    FAMILY
    CATEGORY DNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,nucleus,nucleolus
    basic FUNCTION
  • exosome-associated protein and thus might regulate its functional activities
  • playing a role with MPP6 and SKIV2L2 in the recruitment of the exosome to pre-rRNA to mediate the 3' end processing of the 5.8S rRNA
  • activator of the DNA-dependent protein kinase (DNA-PK), which is essential for the repair of DNA double-strand breaks (DSBs) and V(D)J recombination
  • associated with DNA repair complex and may promote repair of UV-induced DNA damage
  • is essential for wild-type ciliary beating
  • role for C1D in coordinating the activity of specific dynein isoforms to control ciliary motility
  • C1D projection is involved in the control of interdoublet sliding velocity
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • complex associated with the C1D projection of the central apparatus that PCDP1
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with TRAX (may be to regulate TRAX/Translin complex formation)
  • C1D facilitates ERCC3 DNA repair through direct interaction with ERCC3
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene major autoantigen in patients with the PM-scleroderma overlap syndrome and suggest that the use of recombinant as an autoantibody target may aid in diagnosis of the PM-scleroderma overlap syndrome
    Marker
    Therapy target
    ANIMAL & CELL MODELS