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FLASH GENE
Symbol C19orf46 contributors: mct/npt - updated : 24-04-2009
HGNC name chromosome 19 open reading frame 46
HGNC id 26703
Location 19q13.12      Physical location : 36.494.001 - 36.499.672
Synonym name
  • hypothetical protein LOC163183
  • nesprin 4
    • Synonym symbol(s) FLJ36445
    DNA
    TYPE functioning gene
    STRUCTURE 5.67 kb     8 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    8 - 1541 43.4 404 - -
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrineneuroendocrinepituitary   
    Lymphoid/Immunethymus    
    Reproductivefemale systembreastmammary gland  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a KASH domain (Roux 2009)
  • a transmembrane anchor that tethers to the nuclear membrane followed by a short domain that resides within the lumen between the inner and outer nuclear membrane (Puckelwartz 2009)
  • a luminal domain binding directly to SUN proteins
    • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY unknown/unspecified
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,nucleus
    text in outer nuclear membrane (Roux 2009)
    basic FUNCTION
  • can induce kinesin-mediated cell polarization (Roux 2009)
  • kinesin-1-binding protein that displays Sun-dependent localization to the outer nuclear membrane (Roux 2009)
  • Nesp4 may contribute to microtubule-dependent nuclear positioning (Roux 2009)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component part of the LINC complex with the nesprin and SUN proteins (Puckelwartz 2009)
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS