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FLASH GENE
Symbol C14orf39 contributors: mct - updated : 23-03-2021
HGNC name chromosome 14 open reading frame 39
HGNC id 19849
Corresponding disease
POF18 premature ovarian failure 18
SPGF52 spermatogenic failure 52
Location 14q23.1      Physical location : 60.902.674 - 60.952.764
Synonym name
  • six6 opposite strand transcript 1
    • Synonym symbol(s) POF18, SPGF52, Six6os1
    DNA
    TYPE functioning gene
    STRUCTURE 63.82 kb     18 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned   linked   status
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    15 - 2780 - 587 - 2021 33508233
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N terminus containing two SYCE1 binding regions: one located at the amino acid region from AAs 1–67 and the other from 68–267, and is sufficient to interact with SYCE1 and forms a complex with SYCE3 and SYCP1 thereby initiating SC assembly
    • HOMOLOGY
    interspecies ortholog to murine Six6os1
    Homologene
    FAMILY
    CATEGORY DNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • is essential for the appropriate processing of intermediate recombination nodules before crossover formation
  • conserved role of C14ORF39 in synaptonemal complex (SC) assembly, and important and conserved role for C14ORF39/SIX6OS1 in chromosomal synapsis
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • component of the central element of the synaptonemal complex
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacts with the well-established protein synaptonemal complex central element 1 (SYCE1)
  • both SYCE1-SIX6OS1 binding interfaces are essential for SC assembly