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FLASH GENE
Symbol C14orf166 contributors: shn - updated : 23-05-2012
HGNC name chromosome 14 open reading frame 166
HGNC id 23169
Location 14q22.1      Physical location : 52.456.227 - 52.471.419
Synonym name
  • RLL motif containing 1
  • CLE7 homolog
  • UPF0568 protein C14orf166
  • Synonym symbol(s) CGI-99, CLE, CLE7, LCRP369, RLLM1
    DNA
    TYPE functioning gene
    STRUCTURE 15.19 kb     8 Exon(s)
    MAPPING cloned   linked   status
    Map cen - D14S978 - D14S978 - C14orf166 - D14S1018 - D14S989 - qter
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    8 splicing 1064 - 244 - -
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly Homo sapiensAdult NM_016039.2
    Digestive    moderately Homo sapiensAdultNM_016039.2
     liver   lowly Homo sapiensFetalNM_016039.2
    Endocrinepancreas   highly Homo sapiensAdultNM_016039.2
    Nervous    moderately Homo sapiensFetalNM_016039.2
     brain   lowly Homo sapiensAdult NM_016039.2
    Reproductivefemale systemplacenta  lowly Homo sapiensAdult NM_016039.2
    Respiratory    moderately Homo sapiensFetalNM_016039.2
     lung   lowly Homo sapiensAdultNM_016039.2
    Urinarykidney   lowly Homo sapiensAdultNM_016039.2
     kidney   lowly Homo sapiensFetalNM_016039.2
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal highly Homo sapiensAdultNM_016039.2
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a nuclear location signal at the N-terminal
  • a transactivation domain at the N-terminal
  • a Coiled-coil at the C-terminal
  • HOMOLOGY
    interspecies ortholog to 2700060E02Rik – RIKEN cDNA 2700060E02 gene, Mus musculus
    ortholog to zgc:56576, danio rerio
    Homologene
    FAMILY
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION intracellular,nucleus
    text localized to the nuclear compartment with some labelled foci in the perinuclear region of the cell in interphase and in metaphase
    basic FUNCTION may be involved in the functional regulation of human ninein in the centrosome structure and may also be important in brain development and tumorigenesis
  • an important protein for influenza virus replication
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component forming a dimer with the C-terminal, which overlapped with NIN binding site
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • ninein
  • influenza virus polymerase subunit PA
  • influenza virus polymerase complex
  • mature hepatitis C virus core protein
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS