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FLASH GENE
Symbol BYSL contributors: mct/npt - updated : 24-06-2009
HGNC name bystin-like
HGNC id 1157
Location 6p21.1      Physical location : 41.888.964 - 41.900.782
Synonym name
  • BYSTIN
  • by the ribosomal protein s6 gene, drosophila, homolog-like
  • DNA
    TYPE functioning gene
    STRUCTURE 11.82 kb     7 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    7 - 2005 49.5 437 - Miyoshi (2007)
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivesalivary gland   highly
    Reproductivefemale systemuteruscervix highly
     female systemplacenta  highly
    Skin/Tegumentskin   highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period embryo, pregnancy
    Text in placenta from the 6th week of pregnancy, found in the cytoplasm of the syncytiotrophoblast in the chorionic villi, and in endometrial decidual cells at the utero placental interface (Suzuki 1999)
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY
  • bystin family
  • CATEGORY adhesion
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus,nucleolus
    text colocalizes with trophinin, tastin, and the cytokeratins, suggesting that these molecules form a complex in trophectoderm cells at the time of implantation
    basic FUNCTION
  • binding directly to trophinin and tastin which mediate the homophilic adhesion between trophoblast and endometrial epithelial cells
  • cytoplasmic protein directly binding to trophinin, a cell adhesion molecule potentially involved in human embryo implantation (Fukuda 2008)
  • may play multiple roles in cells, and have a conserved function to facilitate ribosome biogenesis required for cell growth
  • may promote cell proliferation by facilitating ribosome biogenesis, specifically in the production of the 40S subunit
  • plays a key role during the transition from silent trophectoderm to an active trophoblast upon trophinin-mediated cell adhesion (Fukuda 2008)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism purine/pyrimidine
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • target of c-MYC is consistent with a role for bystin in rapid protein synthesis, which is required for actively growing cells (Fukuda 2008)
  • associate with trophinin by presumably forming an active adhesion machinery (Aoki 2000)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in cancers
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS