basic FUNCTION
| antiproliferative p53 dependent component of the DNA damage cellular response pathway |
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at the onset of neurogenesis in single neuroepithelial cells that switch from proliferative to neuron-generating divisions |
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transcriptional regulator |
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switch of neuroectodermal cells from proliferating to neuron generating division |
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implicated in the regulation of cell-cycle progression, differentiation of cell lines as well as the control of cellular apoptosis |
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having a suppressive role in the regulation of CNOT7 deadenylase activity  |
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identified as an important downstream effector of TP53-dependent arrest of proliferation in human fibroblasts transduced by oncogenic Ras  |
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may be a modulator of cell survival and differentiation and could help to protect against cell death by inhibition of necrosis and/or apoptotic signalling pathways  |
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implicated in transcription in the nucleus and cytoplasmic mRNA deadenylation and turnover  |
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complexing with AR via an LxxLL-dependent mechanism and may play a role in prostate cancer via modulating the AR signaling pathway  |
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functions as a novel AR-interacting protein in the repression of AR transcriptional activity, and the 92LxxLL96 motif is not only necessary for the BTG2 and AR interaction, it is also essential for BTG2 repression of AR transcriptional activity  |
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implicated in cell cycle regulation, normal development, and possibly tumor suppression  |
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role for BTG2 as a co-activator for NFE2L2 in up-regulating cellular antioxidant defenses  |
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plays likely an important role in hepatic glucose metabolism.  |
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GCG positively regulates insulin gene expression via BTG2, suggesting that BTG2 has a key function in insulin secretion in pancreatic beta-cells  |
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participates in the regulation of hepatic glucose homeostasis  |
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is required for development of spiral ganglion cells (SGCs)  |
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both BTG1 and BTG2 are required for normal vertebral patterning of the axial skeleton, but each gene contributes differently in specifying the identity along the anterior-posterior axis of the skeleton  |
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BTG2 expression is likely an endogenous cell death inducer at the downstream of TP53 gene, which might be useful for intractable cancer chemotherapy  |
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negatively regulates reactive hypertrophy of cardiomyocyte by negatively regulating RNA accumulation  |
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may function as a tumor suppressor by interfering with the WNT/CTNNB1 signaling pathway in skin cancer cells 8) |