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FLASH GENE
Symbol BTG1 contributors: mct/npt - updated : 08-11-2016
HGNC name B-cell translocation gene 1, anti-proliferative
HGNC id 1130
Location 12q22      Physical location : 92.534.053 - 92.539.673
Synonym name B-cell translocation protein 1
DNA
TYPE functioning gene
STRUCTURE 5.62 kb     2 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status confirmed
Map cen - D12S82 - DSPG3 - D12S1441 - D12S1842 - D12S1992 - DCN - D12S1046 - D12S351 - D12S1699 - D12S1450 - D12S322 - D12S7 - BTG1 - D12S311 - D12S1999 - D12S95 - D12S1120 - (D12S1345 ,D12S1433 ) - D12S1862 - D12S1926 - D12S1119 - D12S2004 - D12S1044 - D12S1121 - D12S1346 - D12S327 - qter
Authors 4st Workshop chrom.12 (97)
Physical map
MRPS6P4 12q21 mitochondrial ribosomal protein S6 pseudogene 4 DUSP6 12q21 dual specificity phosphatase 6 TUWD12 12q21.33 TUWD12 CENPC2 12q21.2-q21.33 centromere protein C2, 140kDa GALNT4 12q21.3-q22 UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 4 (GalNAc-T4) ATP2B1 12q21-q23 ATPase, Ca++ transporting, plasma membrane 1 MRPL2P1 12q21.33 ATPase, Ca++ transporting, plasma membrane 1 FLJ25378 12q22 hypothetical protein FLJ25378 MGC26598 12q22 hypothetical protein MGC26598 DSPG3 12q21.3-q22 dermatan sulfate proteoglycan 3 KERA 12q22 keratocan LUM 12q21.3-q22 lumican DCN 12q13.2 decorin BTG1 12q22 B-cell translocation gene 1, anti-proliferative LOC387872 12 hypothetical gene supported by BC044741 LOC390351 12 similar to 60S ribosomal protein L21 LOC283388 12q22 similar to guanine nucleotide exchange factor (1B384) EEA1 12q21.31 early endosome antigen 1, 162kD LOC341444 12q22 similar to alpha NAC/1.9.2. protein LOC387873 12 LOC387873 NUDT4 12q21 nudix (nucleoside diphosphate linked moiety X)-type motif 4 UBE2N 12q21.33 ubiquitin-conjugating enzyme E2N (UBC13 homolog, yeast) MRPL42 12q22 mitochondrial ribosomal protein L42 SOCS2 12q21.3-q23 suppressor of cytokine signaling 2 LOC144483 12q22 similar to Phosphoglycerate mutase 1 (Phosphoglycerate mutase isozyme B) (PGAM-B) (BPG-dependent PGAM 1) CRADD 12q21.33-q23.1 CASP2 and RIPK1 domain containing adaptor with death domain PLXNC1 12q23.3 plexin C1 NY-REN-58 12q22 NY-REN-58 antigen LOC387874 12 hypothetical gene supported by NM_014886 LOC283398 12q22 similar to Succinyl-CoA ligase [GDP-forming] beta-chain, mitochondrial precursor (Succinyl-CoA synthetase, betaG chain) (SCS-betaG) (GTP-specific succinyl-CoA synthetase beta subunit) KIAA1145 12q22 KIAA1145 protein DAP13 12q23.1 13kDa differentiation-associated protein NR2C1 12q22 nuclear receptor subfamily 2, group C, member 1 FGD6 12q23.1 FYVE, RhoGEF and PH domain containing 6 VEZATIN 12q21.33 FYVE, RhoGEF and PH domain containing 6
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
2 - 4704 - 171 - Iwai (2004)
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   highly
Endocrinepancreas   highly
 thyroid   highly
Lymphoid/Immunelymph node   highly
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period
cell cycle     cell cycle, checkpoint
Text cell cycle, maximally expressed in the G0/G1 phases of the cell cycle
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • conserved N-terminal domain spanning 104-106 AAs, a protein-protein interaction module, which is capable of binding to DNA-binding transcription factors as well as the paralogues CNOT7 (human Caf1/Caf1a) and CNOT8 (human Pop2/Calif/Caf1b), two deadenylase subunits of the Ccr4-Not complex (Winkler 2010)
  • C-terminal regions are less conserved and appear to mediate protein-protein interactions that are unique to each family member, necessary and sufficient to control its stability (Sasajima 2002)
  • HOMOLOGY
    Homologene
    FAMILY
  • Tob/TBG1 family of growth inhibitory gene
  • anti-proliferative gene family
  • CATEGORY tumor suppressor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • negative regulator of cell proliferation (antiproliferative)
  • putative tumor suppressor gene
  • may play an important role in the process of angiogenesis (Iwai 2004)
  • driving the formation of the CCR4 NOT (CAF1) complex
  • implicated in transcription in the nucleus and cytoplasmic mRNA deadenylation and turnover (Winkler 2010)
  • both BTG1 and BTG2 are required for normal vertebral patterning of the axial skeleton, but each gene contributes differently in specifying the identity along the anterior-posterior axis of the skeleton
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • CCR4/NOT complex
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • bound to protein arginine methyltransferase (PRMT) 1 via the box C region, an interaction required for anti-IgM-induced growth inhibition (Hata 2007)
  • cell & other
    REGULATION
    Other degraded by the ubiquitin-proteasome system (Sasajima 2002)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral   translocation    
    in B cell lymphocytic leukemia with translocation t(8;12)(q24;q22)
    tumoral   LOH    
    in endometrial cancer cells
    constitutional     --over  
    in dorsolateral prefontal cortex of schizophrenic patient
    Susceptibility to multiple sclerosis (MS)
    Variant & Polymorphism SNP
  • 3SNP in endometrial cancer cells
  • polymorphisms may influence genetic predisposition for MS, especially in relapse-onset MS patients (Camiņa-Tato 2009)
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS