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FLASH GENE
Symbol BTF3 contributors: mct/npt - updated : 03/10/2008
HGNC name basic transcription factor 3
HGNC id 1125
Location 5q13.2      Physical location : 72.794.249 - 72.801.448
Synonym name
  • nascent-polypeptide-associated complex beta polypeptide
  • RNA polymerase B transcription factor 3
  • Synonym symbol(s) NACB, BTF3a, BTF3b, BETA-NAC
    DNA
    TYPE functioning gene
    STRUCTURE 7.20 kb     6 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    8 splicing 3308 27 206 - Kanno, Green (2007)
  • start codon in exon 2
  • playing a role as a potential new substrate for CK2
  • 7 - 3220 22 162 - Kanno, Green (2007)
  • lacking the first 44 N terminal aminoacid present in BTF3a
  • transcriptionally inactive despite its ability to bind the RNA polymerase II
  • identified as an interaction partner of protein kinase CK2 subunit beta
  • start codon in exon 3
  • EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrinepancreas   highly
    Hearing/Equilibriumear   highly
    Urinarybladder   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectiveadipose  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    mono polymer heteromer , complex
    HOMOLOGY
    interspecies homolog to murine Btf3
    homolog to C.elegans C56C10.8
    Homologene
    FAMILY
  • NAC-beta family
  • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • required for initiation of transcription from promoter elements such as TATA box
  • may be a component of the mechanism by which the AF-1 function of ESR1 stimulates gene transcription
  • acting as a transcription factor and modulator of apoptosis, and differentially expressed in colorectal cancer and glioblastomas
  • CELLULAR PROCESS nucleotide, transcription, initiation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • forming a stable complex with RNA polymerase II
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • forming a stable complex with RNA polymerase II
  • interacting with ESR1
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in pancreatic ductal adenocarcinoma
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS