protein
| ligand for the EGF receptor |
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interacting with ADAM10 (mediates ectodomain shedding of the betacellulin precursor) |
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acts via both the EGF receptor, located on Neural stem cells (NSCs), and ERBB4, located on neuroblasts, with the latter explaining why its effects are distinct from those of EGF itself |
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AREG, BTC, and EREG induced prostaglandin E2 (PGE2) production by upregulating PTGS2 expression through ERK1/2 signaling in granulosa cells |
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is a new ligand of the epidermal growth factor receptor (EGFR) |
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bind and activate all possible heterodimeric combinations of the related ERBB receptors including the highly oncogenic ERBB2/3 dimer, as well as homodimers of ERBB4 |
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binds and activates EGFR and ERBB4 homodimers |
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BTC significantly increased the production of IL8 through the activation of the EGFR-PI3K/Akt-Erk signal pathway in lung cancer cells |
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NGF is an important regulator for the synthesis and secretion of Activin-A and BTC from the beta cells |