basic FUNCTION
| inhibiting TBP-driven RNA polymerase II and III transcription |
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removing TBP from DNA (TATA box) in an ATP-dependent manner |
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ATP-dependent helicase regulating TBP function on POLII promoters in cells |
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Swi2/Snf2 enzyme that specifically displaces TBP from the promoter DNA and regulates transcription globally by generating a highly dynamic TBP pool in the cell |
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TBP, BTAF1, and DR1 establish a regulatory circuit that controls downstream core promoter element-dependent versus TATA-dependent transcription b |
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negatively regulates TBP and DR1 binding to active promoters  |
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not only displaces TBP, but blocks its hydrophobic surface patch to prevent interactions with DNA or other factors that bind to the concave surface  |