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Symbol BTAF1 contributors: mct/npt - updated : 01-06-2012
HGNC name BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa (Mot1 homolog, S. cerevisiae)
HGNC id 17307
Location 10q23.32      Physical location : 93.683.735 - 93.790.078
Synonym name
  • TATA box binding protein (TBP) associated factor, RNA polymerase 2D
  • TBP associated factor 172
  • ATP-dependent helicase BTAF1
  • modifier of transcription 1
    • Synonym symbol(s) MOT1, TAF172, TAF-172, TAFII170, TAF2D2, MGC138406, KIAA0940
    EC.number 3.6.1.-
    DNA
    TYPE like-sequence
    SPECIAL FEATURE arranged in tandem
    STRUCTURE 106.35 kb     38 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence alternative promoter
    motif
    text structure multiple transcription start sites
    MAPPING cloned Y linked N status provisional
    Physical map
    IFIT4 10q23.3 interferon-induced protein with tetratricopeptide repeats 4 LOC389994 10 similar to Interferon-induced protein with tetratricopeptide repeats 1 (IFIT-1) (Interferon-induced 56 kDa protein) (IFI-56K) LOC387699 10 similar to Interferon-induced protein with tetratricopeptide repeats 1 IFIT1 10q25-q26 interferon-induced protein with tetratricopeptide repeats 1 IFIT5 10q23.3 interferon-induced protein with tetratricopeptide repeats 5 LOC387700 10 similar to expressed sequence AW210596 PANK1 10q22.3-q23 pantothenate kinase 1 FLJ37201 10q23.32 hypothetical protein FLJ37201 MPHOSPH1 10q23.33 M-phase phosphoprotein 1 LOC119358 10q23.32 similar to Small nuclear ribonucleoprotein Sm D2 (snRNP core protein D2) (Sm-D2) HTR7 10q22-q24 5-hydroxytryptamine (serotonin) receptor 7 (adenylate cyclase-coupled) RPP30 10q23.32-q23.33 ribonuclease P (30kD) ANKRD1 10q23.33 ankyrin repeat domain 1 (cardiac muscle) LOC387701 10 LOC387701 MGC34007 10q23.33 hypothetical protein MGC34007 MGC16202 10q23.33 hypothetical protein MGC16202 FLJ37306 10q23.32 hypothetical protein FLJ37306 LOC387702 10 similar to hypothetical protein FLJ25224 PPP1R3C 10q23-q24 protein phosphatase 1, regulatory (inhibitor) subunit 3C LOC389995 10 similar to Glyceraldehyde 3-phosphate dehydrogenase, liver (GAPDH) TNKS2 10q23.3 tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2 C10orf13 10q23.33 chromosome 10 open reading frame 13 BTAF1 10q22-q23 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa (Mot1 homolog, S. cerevisiae) CPEB3 10q23.33 cytoplasmic polyadenylation element binding protein 3 FLJ20445 10q23.33 hypothetical protein FLJ20445 LOC389996 10 similar to MAP/microtubule affinity-regulating kinase 2 isoform a; ELKL motif kinase 1; ELKL motif kinase IDE 10q24 insulin-degrading enzyme KIF11 10q24.1 kinesin family member 11 LOC283014 10q23.33 similar to eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa; eukaryotic translation initiation factor 2, subunit 2 (beta, 38kD ); eukaryotic initiation factor 2-beta HHEX 10q24 hematopoietically expressed homeobox SEC15L1 10q23.33 SEC15-like 1 (S. cerevisiae) CYP26C1 10q23.33 cytochrome P450, family 26, subfamily C, polypeptide 1 CYP26A1 10q23-q24 cytochrome P450, family 26, subfamily A, polypeptide 1 LOC389997 10 similar to Saccharomyces cerevisiae Nip7p homolog LOC387703 10 similar to ATP-dependent DNA helicase II, 70 kDa subunit (Lupus Ku autoantigen protein p70) (Ku70) (70 kDa subunit of Ku antigen) (Thyroid-lupus autoantigen) (TLAA) (CTC box binding factor 75 kDa subunit) (CTCBF) (CTC75) LOC389998 10 similar to 60S ribosomal protein L17 (L23) FER1L3 10q23.3 fer-1-like 3, myoferlin (C. elegans) C10orf3 10q23.33 chromosome 10 open reading frame 3 GPR120 10q23.33 G protein-coupled receptor 120 RBP4 10q24 retinol binding protein 4, plasma PDE6C 10q24 phosphodiesterase 6C, cGMP-specific, cone, alpha prime C10orf4 10q23.33 chromosome 10 open reading frame 4 LGI1 10q24 leucine-rich, glioma inactivated 1 FLJ33990 10q23.33 hypothetical protein FLJ33990 PSMD4P2 10q23.33 proteasome (prosome, macropain) 26S subunit, non-ATPase, 4, pseudogene 2 PLCE1 10q23 phospholipase C, epsilon 1 AD24 10q23.33 AD24 protein KIAA0608 10q23.33 KIAA0608 protein
    regionally located located between D10S185 and WI-1183
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    38 - 7054 206.7 1849 - 2000 10642510
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver    
    Endocrinepancreas    
    Lymphoid/Immunethymus   highly
    Nervousbrain    
    Reproductivemale systemprostate   
    Respiratoryrespiratory tracttrachea  highly
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoieticbone marrow   
    Connectivebone   
    Epithelialsecretoryglandularendocrine 
    Lymphoid    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • . an amino-terminal TBP binding region of approximately 90–140&
    • 8201;kDa with predicted HEAT repeats
  • nuclear localization signal (NLS)
  • DEAD/DEAH (Asp-Glu-Ala-Asp/His) box
  • helicase conserved C-terminal domain, with Swi2/Snf2-type ATPase domain
    • HOMOLOGY
    interspecies homolog to yeast S.cerevisiae Mot1
    homolog to Drosophila Tis11
    Homologene
    FAMILY
  • SNF2/RAD54 helicase family
  • SNF2/SWI2 family of DNA targeted ATPases
    • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • inhibiting TBP-driven RNA polymerase II and III transcription
  • removing TBP from DNA (TATA box) in an ATP-dependent manner
  • ATP-dependent helicase regulating TBP function on POLII promoters in cells
  • Swi2/Snf2 enzyme that specifically displaces TBP from the promoter DNA and regulates transcription globally by generating a highly dynamic TBP pool in the cell
  • TBP, BTAF1, and DR1 establish a regulatory circuit that controls downstream core promoter element-dependent versus TATA-dependent transcription b
  • negatively regulates TBP and DR1 binding to active promoters
  • not only displaces TBP, but blocks its hydrophobic surface patch to prevent interactions with DNA or other factors that bind to the concave surface
    • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • component of the B-TFIID complex with TBP
    • INTERACTION
    DNA binding
    RNA
    small molecule nucleotide,
  • ATP
    • protein
  • binding to TBP
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS