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FLASH GENE
Symbol BSX contributors: mct - updated : 14/11/2008
HGNC name brain-specific homeobox
HGNC id 20450
Location 11q24.1      Physical location : 122.848.357 - 122.852.379
Synonym symbol(s) BSX1
DNA
TYPE functioning gene
STRUCTURE 4.02 kb     3 Exon(s)
MAPPING cloned Y linked N status confirmed
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
3 - 702 25.8 233 - Chu (2007)
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Reproductivefemale systemovary  lowly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • an homeobox DNA-binding domain
    • HOMOLOGY
    interspecies homolog to chimpanzee BSX (99.6 pc)
    homolog to rattus Bsx (94.8 pc)
    homolog to murine Bsw (96.1 pc)
    Homologene
    FAMILY
  • distal-less homeobox family
    • CATEGORY regulatory , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • functioning as transcriptional activator
  • being essentiel for normal postnatal growth and nursing
  • being an essential factor for neuronal neuropeptide Y and agouti-related peptide function and locomotory behavior in the control of energy balance
  • important molecular marker for early embryonic stages of epiphysis development, being specifically expressed in this neural structure (Cremona 2004)
  • required for locomotory behavior, hyperphagia, and expression of the hypothalamic neuropeptides Npy and Agrp, which regulate feeding behavior and body weight (sakkou 2007)
  • essential factor for NPY/AgRP neuronal function and locomotory behavior in the control of energy balance (Sakkou 2007)
    • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding to specific sequence
    RNA
    small molecule
    protein
  • AGRP is a common orexigenic target gene of NR3C1 and BSX
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS