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FLASH GENE
Symbol BSG contributors: mct/ - updated : 12-04-2016
HGNC name basigin (OK blood group)
HGNC id 1116
Corresponding disease
OK OK blood group
Location 19p13.3      Physical location : 571.324 - 583.492
Synonym name
  • basigin, cell differentiation antigen 147, identified by monoclonal antibody VM8D6
  • collagenase stimulatory factor
  • extracellular matrix metalloproteinase inducer
  • M6 leukocyte activation antigen
  • tumor cell-derived collagenase stimulatory factor
  • CD147 antigen
  • Synonym symbol(s) CD147, CD157, EMMPRIN, TCSF, M6, basigin, 5F7
    DNA
    TYPE functioning gene
    STRUCTURE 12.17 kb     8 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Binding site   transcription factor
    text structure Sp1, EGR2, AP1, TFII binding sites important for transcription in macrophages
    MAPPING cloned Y linked N status provisional
    Physical map
    LOC390871 19 similar to CXYorf1-related protein LOC390872 19 similar to Olfactory receptor 4F3 LOC388486 19 similar to bA476I15.3 (novel protein similar to septin) LOC390873 19 similar to capicua homolog LOC388487 19 LOC388487 PPAP2C 19p13 phosphatidic acid phosphatase type 2C KIAA1193 19p13.3 phosphatidic acid phosphatase type 2C THEG 19p13.3 Theg homolog (mouse) KIAA1957 19p13.3 KIAA1957 FLJ40059 19p13.3 hypothetical protein FLJ40059 MADCAM1 19p13.3 mucosal vascular addressin cell adhesion molecule 1 LOC91978 19p13.3 hypothetical gene supported by BC009520 CDC34 19p13.3 cell division cycle 34 GZMM 19p13.3 granzyme M (lymphocyte met-ase 1) BSG 19p13.3 basigin (OK blood group) HCN2 19p13.3 hyperpolarization activated cyclic nucleotide-gated potassium channel 2 POLRMT 19p13.3 polymerase (RNA) mitochondrial (DNA directed) FGF22 19p13.3 fibroblast growth factor 22 RNF126 19p13.3 ring finger protein 126 FSTL3 19p13 follistatin-like 3 (secreted glycoprotein) PALM 19p13.3 paralemmin LOC126353 19p13.3 hypothetical protein LOC126353 PTBP1 19p13.3 polypyrimidine tract binding protein 1 FLJ11535 19p13.3 hypothetical protein FLJ11535 AZU1 19p13.3 azurocidin 1 (cationic antimicrobial protein 37) PRTN3 19p13.3 proteinase 3 (serine proteinase, neutrophil, Wegener granulomatosis autoantigen) ELA2 19p13.3 elastase 2, neutrophil DF 19p13.3 D component of complement (adipsin) TRAP95 MGC16353 19p13.3 hypothetical protein MGC16353 GPR54 19p13.3 G protein-coupled receptor 54 DRIL1 19p13.3 dead ringer-like 1 (Drosophila) WDR18 19p13.3 WD repeat domain 18 GRIN3B 19p13.3 glutamate receptor, ionotropic, N-methyl-D-aspartate 3B C19orf6 19p13.3 chromosome 19 open reading frame 6 CNN2 21q11 calponin 2 ABCA7 19p13.3 ATP-binding cassette, sub-family A (ABC1), member 7 HA-1 19p13.3 ATP-binding cassette, sub-family A (ABC1), member 7 POLR2E 19p13.3 polymerase (RNA) II (DNA directed) polypeptide E, 25kDa GPX4 19p13.3 glutathione peroxidase 4 (phospholipid hydroperoxidase) KIAA0963 19p13.3 Homo sapiens KIAA0963 protein (KIAA0963), mRNA. STK11 19p13.3 serine/threonine kinase 11 (Peutz-Jeghers syndrome) MGC40084 19p13.3 hypothetical protein MGC40084 ATP5D 19p13.3 ATP synthase, H+ transporting, mitochondrial F1 complex, delta subunit
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - - 1814 - 176 widely expressed in various normal tissues at the mRNA level and upregulated in hepatocellular carcinoma (HCC) tissues compared to in normal tissues 2011 21536654
  • BSG3
  • basigin-3 and basigin-4 were initiated from an alternative promoter
  • glycosylated basigin-3 and basigin-4 were expressed and localized to the plasma membrane
  • could inhibit HCC proliferation and invasion, probably through interaction with basigin-2 as an endogenous inhibitor via hetero-oligomerization
  • 9 - 2024 - 385 - 2011 21536654
  • BSG1
  • 8 - 1676 - 269 - 2011 21536654
  • BSG2
  • BSG3 could inhibit HCC (hepatocellular carcinoma) proliferation and invasion, probably through interaction with basigin-2 as an endogenous inhibitor via hetero-oligomerization
  • 7 - 1609 - 205 widely expressed in various normal tissues at the mRNA level and upregulated in hepatocellular carcinoma tissues compared to in normal tissues 2011 21536654
  • BSG4
  • basigin-3 and basigin-4 were initiated from an alternative promoter
  • glycosylated basigin-3 and basigin-4 were expressed and localized to the plasma membrane
  • EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveesophagus   highly
    Endocrinepancreas    
    Nervousbrain    
    Reproductivemale systemprostate   
    Respiratorylung    
    Skin/Tegumentskin   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow  highly
    Epithelialbarrier/liningretinal pigment epithelium (RPE)  
    Muscularstriatumcardiacmyocardium 
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticthymocyte
    Lymphoid/Immunemacrophage
    Muscularmyocyte
    Skin/Tegumentkeratinocyte
    Visualcone photoreceptor
    VisualMuller cell
    cell lineage broadly expressed on hematopoietic cells
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N-terminal Ig-like domain important for the MMP inducing activity and for cell-cell interactions, presumably through its ability to engage in homophilic interactions
  • three SP1 and two AP2 sites
  • an Ig-like C2-type (immunoglobulin-like) domain
  • an Ig-like V-type (immunoglobulin-like) domain
  • conjugated GlycoP
    HOMOLOGY
    interspecies homolog to murine Bsg
    Homologene
    FAMILY
  • Ig superfamily regulating oral squamous cell carcinoma invasion
  • CATEGORY antigen , receptor
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    text
  • transmembrane glycoprotein that can be released from the cell surface
  • basic FUNCTION
  • plays crucial roles in the development and function of the reproductive, visual, and nervous systems
  • metalloproteinase inducer involved in cell recognition
  • playing a role in normal retinal development and maturation
  • may be playing a role in atherosclerosis development
  • stimulating fibroblasts to synthetize matrix metalloproteinases
  • signaling receptor for cyclophilin B (PPIB)
  • MMP modulator in cancer, development and tissue repair
  • plays pivotal roles in spermatogenesis, embryo implantation, neural network formation and tumor progression
  • via the selective inhibition of specific downstream elements of the Vav1/Rac1 route, contributes to the negative regulation of T-cell responses
  • promotes invasion and metastasis in different tumor types via the induction of MMPs4 and the urokinase-type plasminogen activator system by peritumoral stromal cells
  • stimulates production of matrix metalloproteinases
  • influences beta-amyloid levels by an indirect mechanism involving MMPs that can degrade extracellular beta-amyloid
  • functions in cell adhesion as an inducer of matrix metalloproteinase (MMP) expression in surrounding cells
  • in the myocardium the regulated expression of EMMPRIN is a determinant of MMP activity and may thus play a role in myocardial remodeling
  • involved in several aspects of tumor progression and in addition to its ability to induce vascular endothelial growth factor (VEGF) production, it confers resistance to some chemotherapeutic drugs
  • plays a key regulatory role for MMP activities
  • has a central role in lung tumor progression through its ability to enhance cell proliferation, migration, anchorage-independent growth and cell survival
  • has a fundamental role in tumorigenesis by its ability to regulate Wnt/beta-catenin signaling in cancer
  • regulator of leukocyte transmigration into the CNS in multiple sclerosis
  • BSG and ADAM12 play a major role in cancer invasion and metastasis owing to the fact that they are directly related to the cell microenvironment and extracellular matrix (ECM) degradation
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • subunit of gamma-secretase
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • complexing to MMP1 at the tumor cell surface
  • SPN interacts with BSG and ITGB2 in two distinct but similarly reorganized complexes
  • specific binding to GP6 (platelet GP6 is a novel receptor for BSG and can mediate platelet rolling via GP6-BSG interaction)
  • interact with a wide variety of molecules at the cell surface, such as cyclophilins, integrins, caveolin-1, monocarboxylate transporters
  • is a SNAI2 target gene in the signaling cascade TGFB1&
  • 8594;PI3K/Akt&
    8594;GSK3B&
    8594;SNAI1&
    8594;SNAI2&
    8594;BSG
  • BSG release in microvesicles can be mediated by stimulation of GPER1 in uterine epithelial cells, suggesting that inappropriate stimulation or expression of this receptor may be significant in uterine pathology
  • BSG, which binds to the platelet-specific collagen receptor glycoprotein (GP6), is expressed in a range of cell types including platelets and leukocytes, and has been implicated in neoplastic disease and atherosclerotic coronary disease
  • BSG an SLC3A2 form a complex on the cell plasma membrane of several cancers
  • extracellular PPIA stimulated cell proliferation through BSG by activating ERK1/2 signaling pathway
  • PPIA secreted in response to inflammatory stimuli binds to the cell surface via its receptor BSG and induces secretion of various inflammatory cytokines
  • RING1 inhibits BSG capability promoting melanoma cell migration
  • cell & other
    REGULATION
    Other regulated by growth factors, hormones, glycosylation and membrane shedding
    expression is regulated via a reactive oxygen species-dependent JNK pathway
    ASSOCIATED DISORDERS
    corresponding disease(s) OK
    related resource Blood Group Antigen Mutation Database
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in melanoma cells, and in malignant gliomas
    constitutional     --over  
    leads to the inhibition of NFAT (nuclear factor of activated T-cells) activity induced by Vav1, a Rac1 exchange factor
    tumoral     --over  
    in squamous-cell carcinomas, pancreatic, chromophobic kidney, hepatocellular or medullary breast adenocarcinomas as well as glioblastoma multiforme
    tumoral     --over  
    might contribute to growth and angiogenesis of gastric carcinoma (a good marker for local invasion and prognosis)
    constitutional     --over  
    in myocardium from patients with dilated cardiomyopathy
    constitutional     --over  
    increases in the human left ventricle after acute myocardial infarction
    tumoral     --over  
    increasing levels in lung tumor epithelial cells leads to an enhancement in the metastatic potential of these cells through the upregulation of Wnt/beta-catenin signaling
    tumoral     --over  
    SLC3A2 and BSG were significantly upregulated in non-small cell lung cancer cells, and their expression levels were significantly correlated
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • serum BSG and ADAM12 values and urine ADAM12 values may be useful markers in prostate cancer
  • Plasma PPIA and BSG can serve as indicators of renal disease progression in type 2 diabetes patients
  • Therapy target
    SystemTypeDisorderPubmed
    immunologyautoimmunemultiple sclerosis
    novel therapeutic target in multiple sclerosis
    tumor  
    might be a potential target for therapeutic antitumor drugs
    cancer  
    because of its relative abundant expression and its accessibility as a cell surface molecule on a wide variety of tumors, would make an attractive target for the development of anticancer therapies such as inhibition by antibodies or small molecule inhib
    cancerdigestiveliver
    potential target for the treatment and prevention of hepatocellular carcinoma
    cancerdigestiveliver
    potential therapy for hepatocellular carcinoma by targeting BSG or BSG-PPIA interaction
    ANIMAL & CELL MODELS