basic FUNCTION
| serine/threonine kinase |
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acting as a checkpoint kinase upon DNA damage induced by UV irradiation or methyl methane sulfonate (Lu 2004) |
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may be an autoantigen involved in the pathogenesis of small-cell lung cancer -associated limbic encephalitis |
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required for neuronal polarization (Kishi 2005) |
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an alternative splice form of SadB encoding a short SADB Ser-Thr kinase is localized to centrosomes, and controls centrosome duplication through phosphorylation of gamma-tubulin (Alvarado-Kristensson et al, 2009) |
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controls centrosome homeostasis by regulating phosphorylation of gamma-tubulin and regulates cell cycle progression (Alvarado-Kristensson et al, 2009) |
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BRSK2 and BRSK1 (its homologue, SAD-B) kinases may regulate neuronal polarization, presynaptic vesicle clustering and axon termination |
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BRSK1, BRSK2 are crucial for establishing neuronal polarity, and BRSK1 has also been shown to regulate neurotransmitter release presynaptically |
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ER stress may reduce BRSK2 protein and change BRSK2 subcellular localization, which in turn alleviate ER stress-induced apoptosis |
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BRSK2 level is elevated in response to ER stress, providing an example of ER stress-mediated transcription of a kinase |
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play an essential role in neuronal polarization |
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is a pancreas-specific mediator of incretin response in islet beta cells |
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stimulates cytoskeletal remodeling of F-actin, which is required for the trafficking and fusion of insulin secretory granules to the plasma membrane |
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function as the “yin and yang” of MTOR signaling in pancreatic islet beta cells |
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may also play a role in controlling satiety |
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BRSK1, BRSK2 are required for axon specification and arborization in subsets of neurons |
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involved in axonogenesis and the polarization of cortical neurons |
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