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FLASH GENE

Symbol

BRSK1

contributors: shn/npt/pgu - updated : 01-04-2010

HGNC name	BR serine/threonine kinase 1
HGNC id	18994

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	19q13.42      Physical location : 55.795.533 - 55.823.901
Synonym name	SAD1 kinase
	protein kinase SAD1A
Synonym symbol(s)	KIAA1811, FLJ43009, SAD-B, SAD1, SADB
EC.number	2.7.11.1

DNA

TYPE	functioning gene
STRUCTURE	28.37 kb     19 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

Map	cen - D19S880 - D19S605 - BRSK1 - D19S877 - D19S891 - qter

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_032430 19 - 3109 NP_115806 - 778 gray matter of the brain, spinal cord, in both axonal and dendritic processes of cultured hippocampal 2005 15705853

EXPRESSION

Type	restricted

expressed in

(based on citations)

organ(s)

System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Nervous brain basal nuclei corpus callosum   moderately   brain limbic system hippocampus   highly   brain diencephalon amygdala   moderately   brain basal nuclei caudate nucleus   highly   brain midbrain substantia nigra   highly   brain diencephalon thalamus   highly   brain hindbrain cerebellum   highly   spinal cord       highly Reproductive female system ovary     moderately

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

fetal

Text

brain

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

one UBA domain

HOMOLOGY

interspecies	ortholog to Brsk1, Mus musculus
	ortholog to Brsk1, Rattus norvegicus

intraspecies

paralog to BRSK2

Homologene

FAMILY	protein kinase superfamily
	CAMK Ser/Thr protein kinase family
	AMPK subfamily

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm
	intracellular,nucleus,chromatin/chromosome,centromere
text	DNA damage induced by UV or methyl methane sulfonate caused translocation from cytoplasm to nucleus

basic FUNCTION	acting as checkpoint kinase upon DNA damage induced by UV or methyl methane sulfonate
	required for neuronal polarization
	role in the control of centrosome biogenesis and essential for centriole duplication
	its kinase activity controls centrosome homeostasis by regulating phosphorylation of TUBG1

CELLULAR PROCESS	cell cycle, checkpoint

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule	nucleotide,
	ATP

protein

gamma tubulin, TUBG1

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS