Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol BRMS1 contributors: mct/npt - updated : 12-06-2013
HGNC name breast cancer metastasis-suppressor 1
HGNC id 17262
Location 11q13.1      Physical location : 66.104.803 - 66.112.582
Synonym name tumor suppressor gene(s), chromosome 11
Synonym symbol(s) FLJ39177, TSG11C, DKFZP564A063
DNA
TYPE functioning gene
STRUCTURE 7.78 kb     10 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status confirmed
Map cen - D11S1883 - PYGM PYGM - MEN1 MEN1 - [D11S4946 - D11S4940 - D11S4947 - D11S1783 - D11S4939 - D11S4938 - D11S4937 ] - D11S449 - D11S4748 - D11S460 -D11S4908 - SART1 - CATSPER1 - GAL3ST3 - SF3B2 - PACS1 - ((D11S913 - RAB1B - RIN1 - TSG11C - B3GNT6 - SLC29A2 - MRPL11 - DPP3 - ACTN3 )) - D11S987 - FGF3 - qter
Authors Nord (99), Zainabadi(05)
Text [LOH in follicular thyroid tumors without mutations in MEN1 ], ((FRA11A ))
Physical map
P5326 11q13.1 hypothetical protein p5326 DRAP1 11q13.3 DR1-associated protein 1 (negative cofactor 2 alpha) FLJ32880 11q13.1 hypothetical protein FLJ32880 SART1 11q12-q13 squamous cell carcinoma antigen recognised by T cells MGC11102 11q13.1 hypothetical protein MGC11102 BANF1 11q13.1 barrier to autointegration factor 1 CST6 11q13.2 cystatin E/M CATSPER1 11q12.1 cation channel, sperm associated 1 GAL3ST2 11q13 cation channel, sperm associated 1 SF3B2 11cen-q23 splicing factor 3b, subunit 2, 145kDa PACS1 11q13.1 phosphofurin acidic cluster sorting protein 1 KLC2 11q13.1 phosphofurin acidic cluster sorting protein 1 RAB1B 11q12 RAB1B, member RAS oncogene family MGC50896 11q13.1 hypothetical protein MGC50896 YIF1 11q13 Yip1 interacting factor homolog (S. cerevisiae) MGC33486 11q13.1 hypothetical protein MGC33486 LOC387783 11 LOC387783 CD164L1 11q13 CD164 sialomucin-like 1 RIN1 11q13.2 Ras and Rab interactor 1 BRMS1 14q13.1 breast cancer metastasis-suppressor 1 B3GNT6 11q13.1 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 6 SLC29A2 11q13 solute carrier family 29 (nucleoside transporters), member 2 LOC387784 11 LOC387784 NXF 11q13 HLH-PAS transcription factor NXF MRPL11 11q13.3 mitochondrial ribosomal protein L11 MGC35521 11q13.1 pellino 3 alpha DPP3 11q12-q13.1 dipeptidylpeptidase 3 BBS1 11q13 Bardet-Biedl syndrome 1 LOC254359 11q13.1 hypothetical protein LOC254359 ACTN3 11q13 actinin, alpha 3 CTSF 11q13.1-q13.3 cathepsin F FLJ10786 11q13.1 hypothetical protein FLJ10786 CCS 11q13 copper chaperone for superoxide dismutase
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
10 - 1455 28.3 246 - 2008 18276787
10 - 1360 33.6 290 - 2008 18276787
- - - - 215 in hepatocellular carcinoma (HCC) cells 2013 23643861
  • identical to the major BRMS1 variant (BRMS1.v1) except for missing base pairs 683-775
  • lacking a functional nuclear localization sequence
  • potential role in regulating cell apoptosis and tumor growth in HCC
  • EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Lymphoid/Immunetonsils   highly
    Nervousbrain    
    Respiratoryrespiratory tractlarynx  highly
    Visualeyeuveachoroid  
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialbarrier/liningretinal pigment epithelium (RPE)  
    Lymphoid    
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • both nuclear import and export signals enabling its nucleo-cytoplasmic shuttling
  • two predicted nuclear localization sequences (NLS) that are located near the C-terminus (amino acids 198-205 and 238-244, NLS1 and NLS2 respectively, with an important role for NLS2 in the cytoplasm that is critical for metastasis suppression and is distinct from nuclear localization
  • HOMOLOGY
    Homologene
    FAMILY
  • BRMS1 family
  • CATEGORY tumor suppressor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    text
  • predominantly nuclear protein that suppresses metastasis in multiple human and murine carcinoma cell lines
  • cytoplasmic BRMS1 restricts melanoma progression while nuclear BRMS1 possibly promotes melanoma cell invasion
  • basic FUNCTION
  • may be a mediator of metastasis suppression in breast carcinoma
  • inhibits metastases in multiple organs by blocking several steps in the metastatic cascade
  • regulate the expression of multiple metastasis-associated microRNAs (miR-10b, -373, -520C, -146a, -146b, and -335) in breast carcinoma cells
  • suppresses metastasis without affecting primary tumorigenesis
  • potential role of BRMS1 in regulating Hepatocellular carcinoma apoptosis and metastasis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • member of mSin3-HDAC transcription co-repressor complex
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting wth SPP1 (regulates SPP1 transcription by abrogating NF-kappaB activation)
  • recruits HDAC1 to the NF-kappaB binding site of the PLAU promoter, modulates histone acetylation of RELA on the PLAU promoter, leading to reduced NF-kappaB binding activity on its consensus sequence, and reduced transactivation of PLAU expression
  • association of SNX6 with breast cancer metastasis suppressor 1 (BRMS1) protein
  • ING4 is a downstream target of BRMS1 in regulating tumor angiogenesis
  • inhibits the activity of NFKB1, a well-known transcription factor that plays significant roles in tumor progression. Moreover, and coordinately regulates the expression of metastasis-associated microRNA known as metastamir (
  • CUL3, a component of E3 ubiquitin ligase, is a new binding partner of BRMS1 and the interaction between BRMS1 and CUL3 is mediated by the SPOP adaptor protein
  • suppresses osteopontin (SPP1) expression in Hepatocellular carcinoma cells (HCC) and there is a negative correlation between BRMS1 and SPP1 mRNA expression in HCC tissues
  • induces polyubiquitination of EP300, resulting in its proteasome-mediated degradation
  • cell & other
    REGULATION
    Other ubiquitination-dependent degradation by the CUL3–SPOP complex is a novel regulatory mechanism of BRMS1 and this regulation is important for breast cancer progression
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral   amplification    
    in oral squamous cell carcinoma
    tumoral   deletion    
    in cervical carcinoma
    tumoral   LOH    
    in prostatic cancer
    tumoral   deletion    
    in isolated familial somatotropinoma
    tumoral     --low  
    in breast cancer brain metastasis
    tumoral     --low  
    in metastatic melanoma compared with primary melanoma or dysplastic nevi
    tumoral     --low  
    in hepatocellular carcinoma cells
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerskin 
    may serve an therapeutic target for melanoma patients
    cancerreproductivebreast
    CUL3–SPOP-mediated degradation of BRMS1 could be a new therapeutic target for improving the treatment efficiency of breast cancer
    ANIMAL & CELL MODELS