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FLASH GENE
Symbol BRF1 contributors: mct - updated : 22-01-2013
HGNC name BRF1 homolog, subunit of RNA polymerase III transcription initiation factor IIIB (S. cerevisiae)
HGNC id 11551
Location 14q32.33      Physical location : 105.675.622 - 105.767.329
Synonym name
  • general transcription factor IIIB, 90kD subunit
  • TBP - associated factor, RNA polymerase III, 90kD
  • TATA box binding protein (TBP)-associated factor 3C
  • TATA box binding protein (TBP)-associated factor, RNA polymerase III, GTF3B subunit 2
  • Synonym symbol(s) BRF, GTF3B, TAF3C, TAF3B2, TF3B90, TAFIII90
    DNA
    TYPE functioning gene
    STRUCTURE 106.29 kb     18 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    LOC388022 14 hypothetical gene supported by AK131040 ADSSL1 14q32.33 adenylosuccinate synthase like 1 SIVA 14q32.33 CD27-binding (Siva) protein AKT1 14q32.32 v-akt murine thymoma viral oncogene homolog 1 LOC390508 14 similar to MGC53446 protein MGC23270 14q32.33 hypothetical protein MGC23270 RPS2P4 14q32.33 ribosomal protein S2 pseudogene 4 KIAA0284 14q32.33 KIAA0284 LOC122618 14q32.33 hypothetical protein BC015003 C14orf78 14 chromosome 14 open reading frame 78 C14orf157 14q32.33 chromosome 14 open reading frame 157 C14orf79 14q32.33 chromosome 14 open reading frame 79 CDCA4 14q32.33 cell division cycle associated 4 GPR132 14q32.3 G protein-coupled receptor 132 JAG2 14q32 jagged 2 NUDT14 14q32.33 nudix (nucleoside diphosphate linked moiety X)-type motif 14 LOC390509 14 similar to chloride intracellular channel 6; chloride channel form A BRF1 14q32.33 BRF1 homolog, subunit of RNA polymerase III transcription initiation factor IIIB (S. cerevisiae) BTBD6 14q32 BTB (POZ) domain containing 6 MTA1 14q32.3 metastasis associated 1 CRIP1 7q11.23 cysteine-rich protein 1 (intestinal) CRIP2 14q32.3 cysteine-rich protein 2 LOC388024 14 LOC388024 C14orf80 14q32.33 chromosome 14 open reading frame 80 MGC4659 14q32.33 hole gene ATP5GP3 14q32.33 ATP synthase, H+ transporting, mitochondrial F0 complex, subunit c (subunit 9) pseudogene 3 LOC390510 14 similar to ELK1, member of ETS oncogene family LOC388025 14 similar to Ig alpha-2 chain C region LOC388026 14 similar to Ig epsilon chain C region
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    18 splicing 3677 73.8 677 - 2000 10921893
  • involved in the transcription of tRNA adenovirus VA1,7SL and 5S RNA
  • containing a high mobility group protein 2 (HMG2)-related region in the highly charged C terminal half of the protein and a sequence related to GTF2B in the N terminus
  • - splicing 2057 - 134 - 2000 10921893
    required for transcription of the U6 promoter
    14 splicing 3585 - 473 - 2000 10921893
    18 splicing 3452 - 584 - 2000 10921893
    18 - 3386 - 562 - 2000 10921893
    17 - 3596 - 650 - 2000 10921893
    13 - 2876 - 439 - 2000 10921893
    - - 1170 - 208 - 2000 10921893
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    zinc finger motif
    HOMOLOGY
    Homologene
    FAMILY
  • TFIIB family
  • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleoplasm
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • tRNA 5S,rRNA and virus associated (VA) RNA transcription
  • posttranscriptionally regulates mRNA levels by targeting AU-rich element-bearing transcripts to the decay machinery
  • involved in AU-rich element-mediated mRNA decay (AMD)
  • CELLULAR PROCESS nucleotide, transcription, initiation
    nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component subunit of RNA polymerase III transcription factor TFIIIB,forming a stable complex with casein kinase 2
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
    zinc Zn2+
    protein
  • TBP (TATA-binding protein)
  • MAPKAPK2 inhibits BRF1-dependent AU-rich element mRNA decay through direct phosphorylation
  • HNRNPF is a co-factor in a subset of ZFP36/BRF1-mediated mRNA decay
  • cell & other
    REGULATION
    Phosphorylated by MAPK-activated protein kinase 2 (MAPKAPK2)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --other  
    deregulation of BRF1 and BRF2 expression could be a key mechanism responsible for the observed deregulation of RNA pol III transcription in cancer cells
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • chronic alcohol administration in mice leads to enhanced expression of Tbp, Brf1, tRNA, and 5S rRNA gene transcription in the liver