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FLASH GENE
Symbol BRDT contributors: mct/npt/pgu - updated : 31-03-2010
HGNC name bromodomain, testis-specific
HGNC id 1105
Location 1p22.1      Physical location : 92.414.927 - 92.479.983
Synonym name
  • cancer/testis antigen 9
  • RING3-like protein
  • testis-specific bromodomain protein
  • Synonym symbol(s) BRD6, CT9
    DNA
    TYPE functioning gene
    STRUCTURE 65.06 kb     19 Exon(s)
    Genomic sequence alignment details
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    BARHL2 1p22 BarH-like 2 (Drosophila) LOC388648 1 LOC388648 LOC343474 1p22.2 similar to Phosphorylase B kinase alpha regulatory chain, skeletal muscle isoform (Phosphorylase kinase alpha M subunit) KIAA1221 1p22.1 similar to Phosphorylase B kinase alpha regulatory chain, skeletal muscle isoform (Phosphorylase kinase alpha M subunit) BM-005 LOC391054 1 similar to ribosomal protein L5; 60S ribosomal protein L5 FLJ36760 1p22.2 FLJ36760 protein LOC284696 1p22.2 similar to flap structure-specific endonuclease 1; maturation factor-1; DNase IV LOC391055 1 similar to hypothetical protein LOC164045 1p22.2 hypothetical protein LOC164045 CDC7 1p22 CDC7 cell division cycle 7 (S. cerevisiae) LOC391056 1 similar to RIKEN cDNA 9430077D24 gene TRAP2 1p22 tumor rejection antigen (gp96) pseudogene 2 TGFBR3 1p33-p32 transforming growth factor, beta receptor III (betaglycan, 300kDa) BRDT 1p21-p22 bromodomain, testis-specific ABHD7 1p22.1 abhydrolase domain containing 7 LOC339526 1p22.1 similar to hypothetical protein FLJ20481 LOC126598 1p22.1 similar to template acyivating factor-I alpha LOC284697 1p22.1 similar to agCP5986 KIAA1107 1p22.1 KIAA1107 protein LOC388649 1 similar to 1700028K03 protein GLMN 1p22.1 glomulin, FKBP associated protein FLJ13150 1p22.1 hypothetical protein FLJ13150 GFI1 1p22 growth factor independent 1 EVI5 1p22 ecotropic viral integration site 5 RPL5 1p22.1-p21.3 ribosomal protein L5 LOC388650 1 similar to RIKEN cDNA 2900024C23 M96 1p22.1 likely ortholog of mouse metal response element binding transcription factor 2 CGI-100 1pter-q31.3 CGI-100 protein NY-SAR-41 1p22.1 sarcoma antigen NY-SAR-41 DR1 1p22.1 down-regulator of transcription 1, TBP-binding (negative cofactor 2)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    19 - 3361 107.9 947 - 2005 15647849
    19 - 3156 - 947 - 2005 15647849
    - - 3438 - 960 exclusively expressed in testis 2005 15647849
  • also called BRDT-NY
  • has two bromodomains in N-terminal
  • may have an important role in the process of spermatogenesis and may be correlated with male infertility
  • EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivemouth    
    Reproductivefemale systemovary  moderately
     male systemtestis  specific
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Reproductiveoocyte
    Reproductivespermatogonia
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • two bromodomain motifs, a single bromodomain (BD1 is responsible for selectively recognizing histone H4 tails bearing two or more acetylation marks , and inhibitor JQ1 binds to the Kac binding site of BET bromodomain
  • a PEST sequence (a cluster of proline, glutamic acid, serine, and threonine residues), characteristic of proteins that undergo rapid intracellular degradation
  • HOMOLOGY
    interspecies homolog to Drosophila fsh
    intraspecies homolog to RING3 domain (D6S113E)
    Homologene
    FAMILY
  • bromodomain and extra-terminal (BET) family
  • CATEGORY enzyme , regulatory , transcription factor , receptor membrane serine/threonine kinase
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • involved in protein-protein interaction
  • regulating signal-dependent transcription
  • having a structural role in the remodelling of acetylated chromatin
  • required maternally for proper expression of other homeotic genes involved in pattern formation, such as UBX
  • could also have a new biological role, specific to germ cells, which could be performed by its nonconserved domains
  • implicated in the marked chromatin remodelling that follows histone hyperacetylation during spermiogenesis, the stage of spermatogenesis in which post-meiotic germ cells mature into fully differentiated sperm
  • BET family members have been recognized as essential genes for the replication of viruses and in mediating inflammatory responses
  • BET family proteins recognize acetylated chromatin through their two bromodomains, acting as transcriptional activators or tethering viral genomes to the mitotic chromosomes of their host
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • specifically binds hyperacetylated histone H4 tail depending on the integrity of both bromodomains
  • bind to hyperacetylated chromatin in elongating spermatids and recruit machinery to remove the acetylated histones, replaced by protamines
  • cell & other
    REGULATION
    inhibited by JQ1, a selective and potent inhibitor of BET family bromodomains
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional       gain of function
    at specific stages of spermatogenesis, suggesting that they play an important role in the epigenetic reprogramming during spermatogenesis
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS