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FLASH GENE
Symbol BRD3 contributors: mct - updated : 05-07-2011
HGNC name bromodomain containing 3
HGNC id 1104
Location 9q34.2      Physical location : 136.895.453 - 136.933.141
Synonym name
  • RING3-like
  • Synonym symbol(s) KIAA0043, ORFX, RING3L, RP11-374P20.3, FLJ23227, FLJ41328
    DNA
    TYPE functioning gene
    STRUCTURE 37.71 kb     12 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    regionally located located in a region containing several major histocompatibility complexe (MHC) genes
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    12 - 5673 - 726 - 1997 9373153
    EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrinethyroid   highly
    Lymphoid/Immunelymph node   highly
    Nervousnerve   highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a common domain architecture featuring two N-terminal bromodomains that exhibit high levels of sequence conservation (inhibitor JQ1 binds to the Kac binding site of BET bromodomains)
  • a PEST domain
  • one ET domain
  • a RING finger motif
  • a more divergent C-terminal recruitment domain
  • HOMOLOGY
    interspecies homolog to Drosophila female sterile homeotic gene
    homolog to murine Brd3
    intraspecies homolog to RING3
    paralog to BRD4 (54 p100)
    Homologene
    FAMILY bromodomain and extra-terminal (BET) family
    CATEGORY unknown/unspecified
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • plays a role in allowing cells to enter the proliferative phase of the angiogenic process
  • BET family members have been recognized as essential genes for the replication of viruses and in mediating inflammatory responses
  • BET family proteins recognize acetylated chromatin through their two bromodomains, acting as transcriptional activators or tethering viral genomes to the mitotic chromosomes of their host
  • recruited by GATA1 to both active and repressed target genes in a fashion seemingly independent of histone acetylation
  • "reads" acetyl marks on nuclear factors to promote their stable association with chromatin
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • cofactor that interacts with acetylated GATA1 and this interaction is essential for the targeting of GATA1 to chromatin
  • binds via its first bromodomain (BD1) to GATA1 in an acetylation-dependent manner
  • cell & other
    REGULATION
    inhibited by JQ1, a selective and potent inhibitor of BET family bromodomains
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS