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FLASH GENE
Symbol BRD1 contributors: mct/npt/pgu - updated : 01-12-2012
HGNC name bromodomain containing 1
HGNC id 1102
Location 22q13.33      Physical location : 50.166.937 - 50.218.452
Synonym name BR140-like protein
Synonym symbol(s) DKFZP434B094, BRL, BRPF1, BRPF2, BR1
DNA
TYPE functioning gene
STRUCTURE 51.52 kb     12 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Map cen - D22S274 - D22S1141 - FBLN1 - D22S1170 - D22S1169 - BRD1 - KIAA0685 - qter
Authors Gene Map (98)
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
12 - 4617 119.4 1058 - 1999 10602503
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrinepancreas    
Nervousbrain   highly Homo sapiensBRD1 mRNA
Reproductivemale systemtestis  highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connective    
Epithelialsecretoryglandularendocrine 
Epithelialsecretoryglandularexocrine 
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a bromodomain of some 100AA
  • a PWWP motif
  • two PHD fingers, for potential interactions with histones, and PHD1 specifically recognizes the N-terminal tail of unmodified histone H3 (unH3), important to localize at target genes
  • a motif called PZPM (PHD/Zn-knuckle/PHD Motif)
  • four potential LXXLL motifs
  • four predicted nuclear localization signals (NLS)
  • HOMOLOGY
    intraspecies homolog to BRPF1, BRPF3
    Homologene
    FAMILY
  • RING finger protein family
  • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • involved in protein-protein interaction, regulating signal-dependent transcription
  • bridge the association of MYST3 and MYST4 with ING5 and MEAF6
  • play a key role in assembling and activating MYST3/MYST4 acetyltransferase complexes
  • MYST2-BRD1 complex is the major H3K14 HAT required for transcriptional activation of erythroid developmental regulator genes
  • plays important roles in developmental and disease processes
  • scaffold component in a couple of histone acetyltransferase (HATs) complexes
  • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • component of chromatin remodeling complexes
  • MYST3 and the related factor MYST4 form tetrameric complexes with ING5 (inhibitor of growth 5), MEAF6 (Esa1-associated factor 6 ortholog), and the bromodomain-PHD finger protein BRPF1, -2, or -3
  • subunit of the KAT6A/KAT6A H3 HAT complex
  • forms a novel HAT complex with MYST2 and regulates erythropoiesis
  • INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Zn2+
  • protein
  • BRPF1, BRD1, BRPF3 bridge the association of KAT6A and KAT6B with ING5 and MEAF6
  • bridges MYST2 and its activator protein, ING4
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to schizophrenia and bipolar affective disorder
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • Brd1-deficient embryos showed severe anemia because of impaired fetal liver erythropoiesis