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FLASH GENE
Symbol BPY2 contributors: - updated : 21-10-2006
HGNC name basic charge, Y-linked, 2
HGNC id 13508
Location Yq11      Physical location : 25.130.409 - 27.198.251
Synonym name
  • testis specific basic protein on Y, 2
  • variable charge, Y chromosome, 2 protein
  • variable charge, Y-linked, 2
  • Synonym symbol(s) BPY2A, VCY2, VCY2A
    DNA
    TYPE functioning gene
    SPECIAL FEATURE component of a cluster
    text three nearly identical copies, two of them being part of a palindromic region
    STRUCTURE 21.00 kb     9 Exon(s)    three Copie(s)
    MAPPING cloned Y linked N status confirmed
    regionally located . in the AZFc deleted region . in the non recombining portion of the Y chromosome
    RNA
    TRANSCRIPTS type messenger
    EXPRESSION
    Type restricted
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Reproductivemale systemtestis  specific
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Reproductivespermatid
    Reproductivespermatocyte
    Reproductivespermatogonia
    cell lineage
    cell lines
    fluid/secretion sperm (ejaculated spermatozoa)
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES basic Hydrophobic
    STRUCTURE
    motifs/domains
  • A nuclear bipartite nuclear localization signal (NLS)
  • one copy of the 30bp unit found in multiple copies in VCXs
  • HOMOLOGY
    Homologene
    FAMILY VCX/Y unit family
    CATEGORY unknown/unspecified
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • may be involved in male germ cell development and male infertility
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS development , reproduction/sex
    text involved in male germ cell development
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein binding UBE3A by its HECT domain
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --other  
    impaired exression in male infertility
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS