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FLASH GENE
Symbol BPNT1 contributors: mct - updated : 27/09/2008
HGNC name 3'(2'), 5'-bisphosphate nucleotidase 1
HGNC id 1096
Location 1q41      Physical location : 220.230.825 - 220.263.191
Synonym name
  • BPntase
  • bisphosphate 3'-nucleotidase
  • Synonym symbol(s) PIP
    EC.number 3.1.3.7
    DNA
    TYPE functioning gene
    STRUCTURE 32.37 kb     9 Exon(s)
    Genomic sequence alignment details
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    UBBP2 1q32 ubiquitin B pseudogene 2 CGI-115 1q41 CGI-115 protein LOC391165 1 similar to 40S ribosomal protein S26 TGFB2 1q41 transforming growth factor, beta 2 LYPLAL1 1q41 lysophospholipase-like 1 LOC388738 1 LOC388738 LOC388739 1 similar to KIAA0663 gene product DKFZp547M236 EPRS 1q41 glutamyl-prolyl-tRNA synthetase BPNT1 1q41 3'(2'), 5'-bisphosphate nucleotidase 1 FLJ10326 1q42.11 mitochondrial isoleucine tRNA synthetase RAB3-GAP150 1q42.12 mitochondrial isoleucine tRNA synthetase MORF4LP1 1q4.1-4.2 mortality factor 4 like pseudogene 1 LOC127086 1q42.11 similar to ATP-dependent DNA helicase II, 70 kDa subunit (Lupus Ku autoantigen protein p70) (Ku70) (70 kDa subunit of Ku antigen) (Thyroid-lupus autoantigen) (TLAA) (CTC box binding factor 75 kDa subunit) (CTCBF) (CTC75) MARK1 1q41 MAP/microtubule affinity-regulating kinase 1 FLJ14146 1q42.11 hypothetical protein FLJ14146 FLJ20605 1q42.11 hypothetical protein FLJ20605 FLJ22390 1q42.11 hypothetical protein FLJ22390 HLX1 1q41-q42.12 H2.0-like homeo box 1 (Drosophila) DUSP10 1q32 dual specificity phosphatase 10
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    9 - 2461 - 308 - Spiegelberg (1999)
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Digestiveesophagus   highly
     pharynx   highly
    Endocrinepancreas    
    Nervousbrain    
    Reproductivemale systemprostate   
    Respiratorylung    
    Urinarykidney   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoieticbone marrow   
    Epithelialsecretoryglandularendocrine 
    Epithelialsecretoryglandularexocrine 
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    two metal binding sites
    secondary structure five alpha helices and eleven beta strands
    HOMOLOGY
    interspecies ortholog to murine Bpnt1
    ortholog to rattus Bpnt1
    homolog to Drosophila CG7789
    homolog to C.elegans ZK430.2
    homolog to Golgi-resident PAP3-phosphatase
    Homologene
    FAMILY magnesium dependent phospho-monoesterase family
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    basic FUNCTION catalysing the removing of the 3'-phosphate from 3'-5' bisphosphate nucleosides by hydrolysis
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism nucleic
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
    magnesium Mg2+
    protein
    cell & other
    REGULATION
    inhibited by lithium (involved in lithium's nephrotoxicicy)
    inositol 1,4-bisphosphate
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS