basic FUNCTION
| bactericidal permeability increasing protein |
|
binding to and neutralizing lipopolysaccharides from the outer membrane of Gram-bacteria lipid transfer / lipopolysaccharide binding protein |
|
activated extracellular regulated kinase (ERK) and AKT1, and increased DNA synthesis in retinal pigment epithelial cells (RPE) and pericytes (RPC) |
|
exhibits strong antimicrobial activity against Gram-negative bacteria and potent endotoxin-neutralizing activity |
|
lipopolysaccharide binding protein with Gram-negative bactericidal activity in the leukocytes |
|
potentially represents a central component of the innate immune system to directly combat microbes and modulate subsequent adaptive immune responses |
|
possible functions of BPI during acute pneumonia and CF (cystic fibrosis)-associated chronic infections in the lung |