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FLASH GENE
Symbol BPI contributors: mct - updated : 25-05-2013
HGNC name bactericidal/permeability-increasing protein
HGNC id 1095
Location 20q11.23      Physical location : 36.932.551 - 36.965.905
Synonym name
  • BPI fold containing family D, member 1
  • CAP 57
  • Synonym symbol(s) CAP57, BPIFD1, rBPI
    DNA
    TYPE functioning gene
    SPECIAL FEATURE component of a cluster
    STRUCTURE 33.35 kb     16 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    16 - 1901 - 487 - -
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    blood / hematopoieticspleen    
    Digestiveintestine    
     mouth    
    Respiratorylung    
    Skin/Tegumentskin appendageshairfollicle   Homo sapiensAdult
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoietic    
    Epithelialabsorptive excretorydigestive epithelium  
    Epithelialbarrier lining    Homo sapiensAdult
    Epithelialbarrier/lininguroepithelium  
    Epithelialsecretoryglandularexocrine 
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticneutrophil Homo sapiensAdult
    Skin/Tegumenthair follicle cell Homo sapiensAdult
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a signal peptide
  • a N terminal basic and hydrophilic, half with a LPS binding site
  • N glycosylation sites
  • a C terminal half slightly acidic with four potential transmembrane segments and an octapeptide important for CETP anchoring in lipoprotein particles
  • conjugated GlycoP
    isoforms Precursor
    HOMOLOGY
    Homologene
    FAMILY LBP-BPI-CETP family
    CATEGORY immunity/defense
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
        intracellular
    intracellular,cytoplasm,cytosolic,granule
    text azurophilic granules of neutrophils
    basic FUNCTION
  • bactericidal permeability increasing protein
  • binding to and neutralizing lipopolysaccharides from the outer membrane of Gram-bacteria lipid transfer / lipopolysaccharide binding protein
  • activated extracellular regulated kinase (ERK) and AKT1, and increased DNA synthesis in retinal pigment epithelial cells (RPE) and pericytes (RPC)
  • exhibits strong antimicrobial activity against Gram-negative bacteria and potent endotoxin-neutralizing activity
  • lipopolysaccharide binding protein with Gram-negative bactericidal activity in the leukocytes
  • potentially represents a central component of the innate immune system to directly combat microbes and modulate subsequent adaptive immune responses
  • possible functions of BPI during acute pneumonia and CF (cystic fibrosis)-associated chronic infections in the lung
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS immunity/defense
    text
  • oxygen independent phagocytosis of Gram- bacteria
  • endotoxin neutralizing molecule
  • PATHWAY
    metabolism
    signaling
    a component
  • major constituent of neutrophils that possesses anti-inflammatory properties
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • GPC4 is a specific binding protein for BPI on retinal pigment epithelial to mediate the activation of ERK1/2, AKT1, and the mRNA expressions of PDGFB and VEGFA
  • cell & other
    REGULATION
    Other regulated by an endogenously occuring anti-inflammatory eicosanoids
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
  • ulcerative colitis (UC)
  • Variant & Polymorphism other
  • association between BPI gene mutation (Lys216Glu) and UC
  • Candidate gene
    Marker
  • circulating BPI could constitute a biomarker of lipid metabolism in subjects with normal glucose tolerance and could help to identify those subjects with preserved endothelial function
  • Therapy target
    ANIMAL & CELL MODELS