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FLASH GENE
Symbol BPHL contributors: mct/npt - updated : 30/09/2008
HGNC name biphenyl hydrolase-like (serine hydrolase; breast epithelial mucin-associated antigen)
HGNC id 1094
Location 6p25      Physical location : 3.118.925 - 3.153.430
Synonym name
  • valacyclovir hydrolase
  • breast epithelial mucin-associated antigen
  • Synonym symbol(s) Bph-rp, MCNAA, D0S2254E, MGC125930 , MGC41865, VACVase
    EC.number 3.1.-.-
    DNA
    TYPE functioning gene
    STRUCTURE 34.25 kb     8 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    LOC285770 6p25.2 similar to FLJ00254 protein C6orf195 6p25.2 chromosome 6 open reading frame 195 LOC340156 6p25.2 hypothetical protein LOC340156 WRNIP1 6p24.3 Werner helicase interacting protein 1 SERPINB1 6p25 serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 1 SERPINB9 6p25 serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 9 SERPINB6 6p25 serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 6 NQO2 6p25-p24.3 NAD(P)H dehydrogenase, quinone 2 LOC391864 6 similar to HIV TAT specific factor 1; cofactor required for Tat activation of HIV-1 transcription LOC221754 6p25.2 similar to dJ40E16.3 (novel gene similar to D. melanogaster CG5327 ) RIPK1 6p25.3-p24.1 receptor (TNFRSF)-interacting serine-threonine kinase 1 BPHL 6p25 biphenyl hydrolase-like (serine hydrolase; breast epithelial mucin-associated antigen) TUBB 6p21.3 tubulin, beta polypeptide MGC8685 6p25 tubulin, beta polypeptide paralog LOC389362 6 LOC389362 C6orf85 6p25.2 chromosome 6 open reading frame 85 DKFZP434F011 6p25.2-p25.1 ion transporter protein C6orf145 6p25.1 chromosome 6 open reading frame 145 D6S2654E 6pter DNA segment on chromosome 6(unique) 2654 expressed sequence LOC389363 6 hypothetical gene supported by AF118652; NM_006541 PRPF4B 6p24.2 PRP4 pre-mRNA processing factor 4 homolog B (yeast) C6orf146 6p25.1 chromosome 6 open reading frame 146 PECI 6p24.3 peroxisomal D3,D2-enoyl-CoA isomerase
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    8 - 1521 - 274 - Kim (2004)
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver   highly
    Reproductivefemale systemovary  highly
    Urinarykidney   highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    intraspecies homolog to biphenyl hydrolase
    Homologene
    FAMILY
  • AB hydrolase superfamily
  • lipase family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    basic FUNCTION
  • serine hydrolase catalyzing the hydrolytic cleavage of carbon-carbon bonds
  • involved in the degradation of polychlorinated biphenyls
  • catalyzing the hydrolytic activation of the antiviral prodrugs valacyclovir and valganciclovir
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    text detoxication
    PATHWAY
    metabolism aminoacid , drug
    signaling
    aminoacid derivatives
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS