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FLASH GENE
Symbol BORCS6 contributors: mct - updated : 06-02-2019
HGNC name BLOC-1 related complex subunit 6
HGNC id 25939
Location 17p13.1      Physical location : -
Synonym name
  • hypothetical protein LOC54785
  • chromosome 17 open reading frame 59
  • lysosome-dispersing protein
  • lyspersin
  • Synonym symbol(s) FLJ20014, PRO2472, C17orf59
    DNA
    TYPE functioning gene
    STRUCTURE 1.91 kb     1 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    1 - 1932 - 357 - 2015 25898167
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • C-terminal domain of lyspersin, is essential and sufficient for BORC-dependent recruitment of ARL8B to lysosomes
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,lysosome
    basic FUNCTION
  • Ragulator-interacting protein, which limits MTOR activity
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • is a LAMTOR1-interacting protein that regulates MTOR activity through its interaction with LAMTOR1 at the lysosome
  • upregulated in CD4+ T cells by either ADRB3 stimulation or cold exposure, suggesting contribution to Treg induction
  • is the linker between BORC and late endosomal/lysosomal adaptor and mitogen activated protein kinase and mechanistic target of rapamycin activator (LAMTOR) complexes
  • interaction of LAMTOR1 with Rag GTPases is required for their cellular co-localization and can be competitively inhibited by BORCS6
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS