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FLASH GENE

Symbol

BOP1

contributors: - updated : 20-09-2006

HGNC name	block of proliferation 1
HGNC id	15519

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	8q24.3      Physical location : 145.486.055 - 145.515.120
Synonym name	likely ortholog of mouse block of proliferation 1
Synonym symbol(s)	KIAA0124

DNA

TYPE	functioning gene
STRUCTURE	29.00 kb     16 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

EXPRESSION

Type

widely

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol blood / hematopoietic spleen       highly Digestive liver       highly Endocrine pancreas       highly Nervous brain       highly Respiratory lung       highly Skin/Tegument skin       highly Urinary kidney       moderately

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / hematopoietic bone marrow     highly Epithelial secretory glandular endocrine   Epithelial secretory glandular exocrine

cell lineage
cell lines
fluid/secretion	lymph

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

seven WD repeats

HOMOLOGY

interspecies	ortholog to murine Bop1
	homolog to Drosophila EG.S2C10.1
	homolog to C.elegans Y48B6A.1

Homologene

FAMILY

CATEGORY

regulatory

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus,nucleolus
text	transient overexpression of BOP1 in cells increased the percentage of multipolar spindles

basic FUNCTION	functioning as a regulator of growth
	may serve as an essential factor in ribosome formation that coordinates processing of the spacer regions in pre-rRNA

CELLULAR PROCESS	cell life, proliferation/growth

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in colorectal cancer

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS