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FLASH GENE
Symbol BOLA2 contributors: mct/npt - updated : 21-11-2019
HGNC name bolA homolog 2 (E. coli)
HGNC id 29488
Location 16p11.2      Physical location : 29.464.914 - 30.205.627
Synonym name
  • bolA-like 2 (E. coli)
  • BolA-like protein 2 member A
  • Synonym symbol(s) My016, BOLA2A, BOLA2AB, FLJ18576, FLJ97101
    DNA
    TYPE functioning gene
    STRUCTURE 1.38 kb     3 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    3 splicing 1030 - 152 - 2016 27519415
    3 - 979 - 123 - 2016 27519415
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinesmall intestine  moderately
     mouthtongue  highly
    Lymphoid/Immunelymph node   moderately
     thymus   predominantly
    Reproductivefemale systemuteruscervix moderately
     female systemovary  moderately
    Skin/Tegumentskin   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivebone   
    cell lineage
    cell lines
    fluid/secretion blood
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    mono polymer heteromer , monomer
    HOMOLOGY
    Homologene
    FAMILY
  • bolA/yrbA family
  • CATEGORY chaperone/stress , transcription factor
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    basic FUNCTION
  • involved in cell proliferation or cell-cycle regulation
  • acting as a transcription regulator
  • heterotrimeric complex can work as a [2Fe-2S](2+) cluster transfer component in cytosolic Fe/S protein maturation pathways
  • BOLA2 plays critical roles in promoting iron overload, tumor growth and tumor hemorrhage (TH)
  • BOLA2 plays an important role in cancer biology and is an independent predictor of prognosis in hepatocellular carcinoma (HCC)
  • participates in iron homeostasis, and its expansion has a potential adaptive role in protecting against iron deficiency
  • involved in the maturation of cytosolic iron-sulfur proteins
  • CELLULAR PROCESS cell cycle
    cell life, proliferation/growth
    nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • monothiol glutaredoxin GLRX3 and BOlA2 function as a [2Fe-2S] chaperone complex
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • apo BOLA2 binds to each Grx domain in the [2Fe-2S] GLRX3 homodimer forming a [2Fe-2S] BOLA2-GLRX3 heterotrimer
  • interactions between GLRX3, BOLA2, and components of the cytosolic iron-sulfur cluster assembly system
  • physically interacts with GLRX3 (glutaredoxin 3) to form a [2Fe–2S]-bridged heterotrimeric complex
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional       loss of function
    BOLA2 haploinsufficiency and deficiency cause mild hypochromic, microcytic, iron-deficiency anemia (pMID: 31668704)
    tumoral     --over  
    in hepatocellular carcinoma
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • Bola2-deficient mice and the mice carrying the deletion showed early evidence of iron deficiency, including a mild decrease in hemoglobin, lower plasma iron, microcytosis, and an increased red blood cell zinc-protoporphyrin-to-heme ratio