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FLASH GENE
Symbol BOC contributors: mct - updated : 26-03-2012
HGNC name Boc homolog (mouse)
HGNC id 17173
Location 3q13.2      Physical location : 112.931.374 - 113.006.303
Synonym name brother of CDO
Synonym symbol(s) UNQ604/PRO1190
DNA
TYPE functioning gene
STRUCTURE 74.93 kb     20 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
20 - 4293 - 1114 - 2002 11782431
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   highly
Digestivemouthtongue  moderately
Lymphoid/Immunethymus   highly
Reproductivefemale systemuterus  highly
 female systemovary  moderately
 male systemprostate  moderately
Respiratorylung   moderately
Visualeye   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectivebone   
cells
SystemCellPubmedSpeciesStageRna symbol
Nervousneuron
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • four Ig repeats
  • three FNIII repeats
  • a single-pass transmembrane domain
  • a 238-residue intracellular region
  • mono polymer complex
    HOMOLOGY
    interspecies ortholog to murine Boc
    intraspecies paralog to CDON
    Homologene
    FAMILY
  • immunoglobulin (Ig)/fibronectin type III repeat family
  • CATEGORY adhesion , receptor membrane
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • involved in myogenic differentiation
  • candidate receptor for the action of SHH as an axon guidance ligand
  • axon-guidance molecule playing a fundamental role in pathfinding during the early patterning of the axon scaffold in the embryonic vertebrate brain
  • CDON and BOC encode cell surface Ig/fibronectin superfamily members linked to muscle differentiation
  • CDON and BOC have specific, selective roles in Shh signaling
  • GAS1, CDON, and BOC play overlapping and essential roles during HH-mediated ventral neural patterning of the mammalian neural tube
  • CELLULAR PROCESS cell life, differentiation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • forming complexes with CDON in a cis fashion via association of both their ectodomains and their intracellular domains
  • APPL1, an interacting partner of AKT1, forms complexes with CDON and BOC in differentiating myoblasts
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding specifically to SHH
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS