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FLASH GENE
Symbol BNIPL contributors: mct/npt - updated : 09-12-2009
HGNC name BCL2/adenovirus E1B 19kD interacting protein like
HGNC id 16976
Location 1q21.2      Physical location : 151.009.028 - 151.020.076
Synonym name
  • Bcl-2/adenovirus E1B 19kDa interacting protein 2 like-2
  • BNIP-2 similar
  • Synonym symbol(s) BNIP2L, PP753, BNIP-S, BNIPL1, BNIPL2
    DNA
    TYPE functioning gene
    STRUCTURE 11.04 kb     11 Exon(s)
    regulatory sequence Binding site   hormone
    MAPPING cloned Y linked N status provisional
    Physical map
    FLJ12528 1q21.3 threonyl-tRNA synthetase ECM1 1q21.1-q21.2 extracellular matrix protein 1 TSRC1 1q21.3 thrombospondin repeat containing 1 FLJ13544 1q21.3 hypothetical protein FLJ13544 MCL1 1q21 myeloid cell leukemia sequence 1 (BCL2-related) ENSA 1q21.2 endosulfine alpha GPP34R 1q21.3 GPP34-related protein DKFZP434A1315 1q21.3 hypothetical protein DKFZp434A1315 CTSS 1q21 cathepsin S CTSK 1q21 cathepsin K (pycnodysostosis) ARNT 1q21 aryl hydrocarbon receptor nuclear translocator HCP1 1q21.3 cytochrome c, somatic pseudogene SETDB1 1q21 SET domain, bifurcated 1 LASS2 1q11 LAG1 longevity assurance homolog 2 (S. cerevisiae) ANXA9 1q21 annexin A9 FLJ11280 1q21.3 hypothetical protein FLJ11280 BNIPL 1q21.2 BCL2/adenovirus E1B 19kD interacting protein like HTCD37 1q21 TcD37 homolog FLJ20519 1q21.3 hypothetical protein FLJ20519 SPEC1 1q21.2 hypothetical protein FLJ20519 AF1Q 1q21 hypothetical protein FLJ20519 MGC29891 1q21.3 hypothetical protein MGC29891 SEMA6C 1q21.2 sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6C FLJ23467 1q21.3 hypothetical protein FLJ23467 LOC388695 1 similar to hypothetical protein SB145 SCNM1 1q21.3 sodium channel modifier 1 TMOD4 1q12 tropomodulin 4 (muscle) TCFL1 1q21 transcription factor-like 1 PIP5K1A 1q22-q24 phosphatidylinositol-4-phosphate 5-kinase, type I, alpha PSMD4 1q21.3 proteasome (prosome, macropain) 26S subunit, non-ATPase, 4 KIAA1441 1q21.3 KIAA1441 protein PIK4CB 1q21 phosphatidylinositol 4-kinase, catalytic, beta polypeptide RFX5 1q21 regulatory factor X, 5 (influences HLA class II expression) SELENBP1 1q21-q22 selenium binding protein 1 PSMB4 1q21 proteasome (prosome, macropain) subunit, beta type, 4 POGZ 1q21.1 pogo transposable element with ZNF domain
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    10 - 2160 - 275 - Qin (2003), Zhou
  • also called BNIP Salpha
  • a complete BNIP2 and CDC42GAP homology domain (BCH) confering a novel apoptotic function
  • - - 2412 - 275 - Qin (2003), Zhou
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Reproductivemale systemprostate   
    Visualeyeretina   
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelial    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a BNIP2 and ARHGAP1 homology (BCH) domain
  • CRAL-TRIO domain
  • HOMOLOGY
    intraspecies homolog to BNIP2
    Homologene
    FAMILY
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    intracellular,nuclear envelope
    basic FUNCTION
  • implicated in the suppression of cell death
  • may be playing an important role in regulation of both pathways for DNA fragmentation and for formation of membrane blebs in apoptotic cells
  • might inhibit cell growth though cell cycle arrest and/or apoptotic cell death pathway(s) (Xie 2005)
  • induce apoptosis and/or necrosis (Zhang 2003)
  • may play its roles in apoptosis through regulating the expression of genes associated with cell apoptosis, growth inhibition and cell proliferation (Xie 2004)
  • promotes the invasion and metastasis of human hepatocellular carcinoma cells (Xie 2007)
  • CELLULAR PROCESS cell life, cell death/apoptosis
    PHYSIOLOGICAL PROCESS
    text inducing DNA fragmentation and membrane blebbing
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • proliferation related protein (macrophage migration inhibitory factor)
  • GEF (growth factor erv1 (S.cerevisiae-like)
  • BCL2 and ARHGAP1
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS