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FLASH GENE
Symbol BNIP2 contributors: mct/npt - updated : 29-09-2009
HGNC name BCL2/adenovirus E1B 19kDa interacting protein 2
HGNC id 1083
Location 15q22.2      Physical location : 59.955.063 - 59.981.642
Synonym symbol(s) NIP2, BNIP-2
DNA
TYPE functioning gene
STRUCTURE 26.42 kb     10 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
FLJ20086 15q21.2 hypothetical protein FLJ20086 LOC145783 15q21.2 hypothetical protein LOC145783 TCF12 15q21 transcription factor 12 (HTF4, helix-loop-helix transcription factors 4) LOC388124 15 LOC388124 FLJ14957 15q21.2 hypothetical protein FLJ14957 FLJ30973 15q21.2 hypothetical protein FLJ30973 GRINL1A 15q22.1 glutamate receptor, ionotropic, N-methyl D-aspartate-like 1A ALDH1A2 15q21.2 aldehyde dehydrogenase 1 family, member A2 AQP9 15q22.1-q22.2 aquaporin 9 LOC145780 15q21.2 hypothetical LOC145780 LIPC 15q21-q22.2 lipase, hepatic ADAM10 15q22 a disintegrin and metalloproteinase domain 10 KIAA1164 15q21.3 hypothetical protein KIAA1164 LOC390587 15 similar to zinc finger protein 444; endothelial zinc finger protein 2 FLJ13213 15q21.3 hypothetical protein FLJ13213 RNF111 15q21 ring finger protein 111 CCNB2 15q21.3 cyclin B2 MYO1E 15q21-q22 myosin IE LDHL 15q21.3 lactate dehydrogenase A -like LOC390588 15 similar to TGF beta-inducible nuclear protein 1 (Hairy cell leukemia protein 1) (HUSSY-29) MGC26690 15q21.3 hypothetical protein MGC26690 GCNT3 15q21.3 glucosaminyl (N-acetyl) transferase 3, mucin type GTF2A2 15q21.2 general transcription factor IIA, 2, 12kDa BNIP2 15q11.2 BCL2/adenovirus E1B 19kDa interacting protein 2 LOC145767 LOC390589 15 similar to ATP-dependent RNA helicase DDX18 (DEAD-box protein 18) (Myc-regulated DEAD-box protein) (MrDb) FOXB1 15q21-q26 forkhead box B1 ANXA2 15q21-q22 annexin A2 NARG2 15q21.3 NMDA receptor-regulated gene 2 RORA 15q21-q22 RAR-related orphan receptor A HCP38 15q21.3 cytochrome c, somatic pseudogene LOC390590 15 similar to RAR-related orphan receptor A isoform a; RAR-related orphan receptor alpha; retinoic acid receptor-related orphan receptor alpha; transcription factor RZR-alpha; ROR-alpha FLJ20136 LOC145741 15q21.3 hypothetical LOC145741 LOC390591 15 similar to nucleophosmin LOC388125 15 similar to hypothetical LOC237397 FLJ38723 15q21.3 hypothetical protein FLJ38723
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
10 - 2533 48.7 435 - Valencia (2007)
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumcardiacmyocardiumhighly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N-terminal EF-hand motif, with caspase cleavage sites (Valencia 2007)
  • a putative calcium binding motif
  • homology to ARHGAP1 non catalytic domain of CdcC42GAP, termed BCH (BNIP2 and Cdc42GAP) homology domain
  • Bcl-2 homology domain 3
  • carboxyl terminal transmembrane domain, with many arginine residues
  • HOMOLOGY
    Homologene
    FAMILY
  • BCL2/adenovirus E1B 19 kd-interacting protein (BNIP) family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nuclear envelope
    basic FUNCTION
  • GTPase activating activity toward CDC42
  • induce apoptosis and/or necrosis (Zhang 2003)
  • induces cell dynamics by recruiting CDC42 via its BCH domain, thus providing a novel mechanism for regulating CDC42 signaling pathway (Zhou 2005)
  • BCH domain-containing protein implicated in programmed cell death (cleaved by caspases during apoptosis) (Valencia 2007)
  • CELLULAR PROCESS cell life, cell death/apoptosis
    cell life, antiapoptosis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • putative substrate of the fibroblast growth factor receptor tyrosine kinase
  • binding to CDC42, by its BCH domain
  • adenovirus E1B,19kDa
  • associating to BCL2
  • interacting with ARHGAP1 (CDC42 GAP)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in neuroblastoma cell lines resulted in massive cell death (Valencia 2007)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS