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FLASH GENE

Symbol

BNIP1

contributors: mct/npt - updated : 08-07-2014

HGNC name	BCL2/adenovirus E1B 19kDa interacting protein 1
HGNC id	1082

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	5q35.1      Physical location : 172.571.444 - 172.591.389
Synonym name	BH3 proapotosis protein
	transformation-related gene 8 protein
	vesicle transport protein SEC20
Synonym symbol(s)	NIP1, E1B19K, SEC20, SEC20L, TRG-8, Qb-SNARE

DNA

TYPE	functioning gene
STRUCTURE	19.95 kb     7 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

text	other transcripts

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_013978 5 - 1157 NP_053581 - 194 - 2004 15272311 also called BNIP1-S1(1-a) lacking the BH3 domain NM_013979 7 - 1388 NP_053582 31.2 271 - 2004 15272311 also called BNIP1-S2(1-b) a highly conserved BH3 domain NM_013980 6 - 1286 NP_053583 - 237 - 2004 15272311 also called BNIP1-S3(1-c) lacking the BH3 domain NM_001205 6 - 1259 NP_001196 - 228 - 2004 15272311

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart       highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Muscular striatum cardiac myocardium highly

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a N terminal 32 AA region
	a putative transmembrane domain
	a fully conserved BH3 domain (apoptosis effector) in the C terminal region, with a highly conserved leucine residue playing an important role not only in the induction of apoptosis but also in the binding of alpha-SNAP, an adaptor that serves as a link between the chaperone ATPase NSF and SNAREs (Nakajima 2004)

HOMOLOGY

Homologene

FAMILY	BH3-only protein family
	BCL2/adenovirus E1B 19 kd-interacting protein (BNIP) family

CATEGORY

regulatory

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,mitochondria
	intracellular,cytoplasm,organelle,membrane
	intracellular,cytoplasm,organelle,endoplasmic reticulum
	intracellular,nuclear envelope
text	predominantly localized to the endoplasmic reticulum (ER)

basic FUNCTION	participates in the formation of the ER network structure, but not in membrane trafficking between the ER and Golgi (Nakajima 2004)
	induce apoptosis and/or necrosis (Zhang 2003)
	ER-specific BNIP1 plays an important role in mitochondrial dynamics by modulating the mitochondrial fission protein DNM1L in a BH3 domain-dependent fashion
	functions as a component of the STX18 SNARE complex and regulates retrograde transport from the Golgi to the endoplasmic reticulum
	mediates photoreceptor apoptosis in response to vesicular fusion defects
	functions as a downstream modulator of RNF186 to direct ER stress-associated apoptotic signaling

CELLULAR PROCESS	cell life, cell death/apoptosis

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component	ER (endoplasmic reticulum)-localized syntaxin 18 (Qa-SNARE) forms a complex with BNIP1 (Qb-SNARE), USE1(Qc-SNARE), SEC22B (R-SNARE) and several peripheral membrane proteins (Aoki 2008)
	component of the complex comprising syntaxin 18, an endoplasmic reticulum (ER)-located soluble N-ethylmaleimide-sensitive factor (NSF) attachment protein (SNAP) receptor (SNARE)(Nakajima 2004)

INTERACTION

DNA

RNA

small molecule

protein	BCL2, like sequence
	BCL2L1
	adenovirus E1B, 19kDa
	BNIP1 colocalizes with RNF185 at mitochondria and is polyubiquitinated by RNF185 through K63-based ubiquitin linkage
	BNIP1 is one of the substrates of RNF186

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS