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FLASH GENE
Symbol BNIP1 contributors: mct/npt - updated : 08-07-2014
HGNC name BCL2/adenovirus E1B 19kDa interacting protein 1
HGNC id 1082
Location 5q35.1      Physical location : 172.571.444 - 172.591.389
Synonym name
  • BH3 proapotosis protein
  • transformation-related gene 8 protein
  • vesicle transport protein SEC20
  • Synonym symbol(s) NIP1, E1B19K, SEC20, SEC20L, TRG-8, Qb-SNARE
    DNA
    TYPE functioning gene
    STRUCTURE 19.95 kb     7 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    text other transcripts
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    5 - 1157 - 194 - 2004 15272311
  • also called BNIP1-S1(1-a)
  • lacking the BH3 domain
  • 7 - 1388 31.2 271 - 2004 15272311
  • also called BNIP1-S2(1-b)
  • a highly conserved BH3 domain
  • 6 - 1286 - 237 - 2004 15272311
  • also called BNIP1-S3(1-c)
  • lacking the BH3 domain
  • 6 - 1259 - 228 - 2004 15272311
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumcardiacmyocardiumhighly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a N terminal 32 AA region
  • a putative transmembrane domain
  • a fully conserved BH3 domain (apoptosis effector) in the C terminal region, with a highly conserved leucine residue playing an important role not only in the induction of apoptosis but also in the binding of alpha-SNAP, an adaptor that serves as a link between the chaperone ATPase NSF and SNAREs (Nakajima 2004)
  • HOMOLOGY
    Homologene
    FAMILY
  • BH3-only protein family
  • BCL2/adenovirus E1B 19 kd-interacting protein (BNIP) family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,nuclear envelope
    text predominantly localized to the endoplasmic reticulum (ER)
    basic FUNCTION
  • participates in the formation of the ER network structure, but not in membrane trafficking between the ER and Golgi (Nakajima 2004)
  • induce apoptosis and/or necrosis (Zhang 2003)
  • ER-specific BNIP1 plays an important role in mitochondrial dynamics by modulating the mitochondrial fission protein DNM1L in a BH3 domain-dependent fashion
  • functions as a component of the STX18 SNARE complex and regulates retrograde transport from the Golgi to the endoplasmic reticulum
  • mediates photoreceptor apoptosis in response to vesicular fusion defects
  • functions as a downstream modulator of RNF186 to direct ER stress-associated apoptotic signaling
  • CELLULAR PROCESS cell life, cell death/apoptosis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • ER (endoplasmic reticulum)-localized syntaxin 18 (Qa-SNARE) forms a complex with BNIP1 (Qb-SNARE), USE1(Qc-SNARE), SEC22B (R-SNARE) and several peripheral membrane proteins (Aoki 2008)
  • component of the complex comprising syntaxin 18, an endoplasmic reticulum (ER)-located soluble N-ethylmaleimide-sensitive factor (NSF) attachment protein (SNAP) receptor (SNARE)(Nakajima 2004)
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • BCL2, like sequence
  • BCL2L1
  • adenovirus E1B, 19kDa
  • BNIP1 colocalizes with RNF185 at mitochondria and is polyubiquitinated by RNF185 through K63-based ubiquitin linkage
  • BNIP1 is one of the substrates of RNF186
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS