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FLASH GENE
Symbol BNC1 contributors: mct - updated : 07-04-2021
HGNC name basonuclin 1
HGNC id 1081
Corresponding disease
POF16 premature ovarian failure 16
Location 15q25.2      Physical location : 83.924.654 - 83.953.468
Synonym name zinc finger protein basonuclin
Synonym symbol(s) BSNC, BASO, BNC, BSN1, HsT19447, POF16
DNA
TYPE functioning gene
STRUCTURE 28.78 kb     5 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
5 - 4627 - 994 - 2006 16891417
5 - 4767 - 987 - 2006 16891417
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Reproductivemale systemtestis    Homo sapiens
Skin/Tegumentskin     Homo sapiens
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialbarrier/liningepidermisstratum basale  Homo sapiens
cells
SystemCellPubmedSpeciesStageRna symbol
Reproductivegerm cell Homo sapiens
Reproductivespermatid Homo sapiens
Reproductivespermatocyte Homo sapiens
Reproductivespermatogonia Homo sapiens
Skin/Tegumentkeratinocyte Homo sapiens
cell lineage germinal cells
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • several binding sites (UBTF and others)
  • three separated pairs of zinc fingers
  • a nuclear localization signal
  • HOMOLOGY
    intraspecies paralog to BNC2
    Homologene
    FAMILY
    CATEGORY transcription factor , transport
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus,nucleoplasm
    intracellular,nucleus,nucleolus
    text
  • midpiece of the flagellum during late spermiogenesis in spermatids
  • shuttle between the nucleus and the cytoplasm, and location correlated with the proliferative potential of the cell
  • basic FUNCTION
  • playing a regulatory role in keratinocyte proliferation and may be also a regulator for rRNA transcription
  • transcription factor that has an unusual ability to interact with promoters of both RNA polymerases I and II
  • like MYC, may coordinate transcriptional activities among the three RNA polymerases, but regulates a distinctive set of pathways, which differ from that regulated by MYC
  • may be having a function related to the potential for cell proliferation
  • cell-type-specific ribosomal RNA (rRNA) gene regulator
  • is required for the maintenance of spermatogenesis
  • regulates epithelial plasticity of mammary epithelial cells and influences outcome of TGFB1 signaling
  • BNC1 might directly cooperate with TAF7L to regulate spermatogenesis
  • BNC1 is a transcription factor that is crucial for spermatogenesis and male fertility
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • part of basonuclin-Pol I complex that transcribes a subset of rDNA
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • HSF2BP is a testis-specific binding protein of HSF2, and is a binding partner of BNC1
  • expression of BNC1 modulates TGFB1-induced epithelial dedifferentiation of mammary epithelial cells
  • BNC1 role in spermatogenesis by directly binding to BNC1 binding elements in the promoter regions of both YBX2 and PAPOLB and inducing transcription of these important spermatogenesis genes
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) POF16
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    by hypermethylation in renal cell carcinoma
    tumoral     --low  
    by hypermethylation in renal cell carcinoma
    tumoral     --low  
    of BNC1 and BNC2 is associated with genetic or epigenetic regulation in hepatocellular carcinoma
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • methylation status of ADAMTS1 and BNC1 in cfDNA shows promise for detecting pancreatic cancer during the early stages when curative resection of the tumor is still possible
  • Therapy target
    ANIMAL & CELL MODELS
  • Bnc1-null male mice were sub-fertile, losing germ cells progressively with age
  • male mice carrying the truncation mutation exhibited progressively fertility loss and testicular premature aging