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Symbol BMP7 contributors: mct/npt - updated : 21-03-2016
HGNC name bone morphogenetic protein 7
HGNC id 1074
Location 20q13.31      Physical location : 55.743.808 - 55.841.707
Synonym name
  • osteogenic protein 1
  • eptotermin alfa
  • Synonym symbol(s) OP1, OP-1
    TYPE functioning gene
    STRUCTURE 97.90 kb     7 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    7 - 4049 - 431 - 1995 7560881
    Type widely
       expressed in (based on citations)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivemouthtongue  highly
    Lymphoid/Immunetonsils   highly
    Nervous      Homo sapiensFetal
     braindiencephalonhypothalamus highly Homo sapiens
     nervecranial nerve  highly
    Urinarykidneynephron  highly Homo sapiensFetal
    Visualeyeuveachoroid highly
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivebone  moderately
    Epithelialbarrier liningretinal pigment epithelium (RPE)  
    Nervouscentral  highly Homo sapiensFetal
    cell lineage
    cell lines
    fluid/secretion lymph
    at STAGE
    physiological period embryo
    Text developing skeletal structure limb, tooth, mesoderm, kidney, eye, trabecular meshwork
  • a TGF beta-like domain
  • mono polymer homomer , dimer
    isoforms Precursor cleaved at a consensus Arg-X-XArg to yield a C terminus mature dimer
    interspecies homolog to rattus Bmp7 (92,02 pc)
    homolog to murine Bmp7 (97,67 pc)
    ortholog to Drosophila decapentaplegic-Vg, DVR family
    intraspecies paralog to BMP5, BMP6
  • TGF-beta family
  • CATEGORY signaling growth factor
    basic FUNCTION
  • putative protease, osteogenic protein
  • isolated from bone matrix, but it may have additional regulatory roles in the morphogenesis and/or function of the kidney, limb bud, tooth, heart, and intestine
  • playing a role in calcium regulation and bone homeostasis
  • stimulating initial dendritic growth in sympathetic neurons through an intracellular fibroblast growth factor signaling pathway
  • important regulator of cell development and differentiation of various organs
  • increasing chick photoreceptor outer segment initiation
  • antagonist of TGFB2 in human trabecular meshwork cells
  • plays an important role during fetal kidney development, and a physiological role mostly in distal nephron
  • promotes differentiation of brown preadipocytes even in the absence of the normally required hormonal induction cocktail
  • playing an important role in promoting brown adipocyte differentiation and thermogenesis
  • having a specific effect on induction of the brown-fat-specific protein UCP1
  • key protein involved in liver organogenesis and development, and playing a role as a kidney- and bone-produced endogenous regulator of hepatocyte health
  • may play an important role in the pathogenesis of myelofibrosis in primary myelofibrosis and are apparently induced by cytokines such as TGFbeta-1
  • can promote and inhibit cell growth in breast cancer cell lines and, in a suitable environment, can also considerably induce breast cancer cell migration and invasion
  • BMP7 signaling through ACVR1 can reduce Wnt signaling via SOST/DKK1 and then inhibits osteogenesis
  • BMP7/JNK signaling regulates remodeling of the cloacal endoderm resulting in a topological separation of the urinary and digestive systems
  • inhibits epithelialization and differentiation of the kidney progenitor cells
  • regulation of BMP7 signaling is critical for renal development and renal disease progression
  • BMP4 and BMP7 induce the white-to-brown transition of primary human adipose stem cells
  • BMP2 and BMP7 both promoted odontogenic and osteogenic differentiation of tooth germ stem cells (hTGSCs)
  • SHH and BMP7, which are expressed in the anterior and posterior hypothalamic ventral midline respectively, together repel hypothalamic axons towards the medial ventral midline
  • BMP7 and EREG expression in late bell-stage human dental papilla contributes to the inductive potential of dental mesenchyme
  • protective BMP7 signaling may be facilitated by stress-inducible SCUBE1 after renal ischemia-reperfusion (I/R)
    PHYSIOLOGICAL PROCESS development , ossification
    a component
    small molecule
  • inducing noggin expression in early skeletogenesis
  • TGFB1 supporting the rapid morphogenesis of heterotopic endochondral bone initiated by TGFB7
  • specifically binds to cell-surface heparan sulfate (HS) and the BMP7-HS interaction is required for BMP7 signaling
  • CHRDL1 reduces BMP7 signaling in healthy proximal tubules, and the loss of this activity upon sloughing of injured epithelia promotes BMP7 signaling in repopulating, dedifferentiated epithelia
  • interactions between mesenchyme-derived FST and epithelial BMP7 play a central role in the morphogenesis, innervation and maintenance of taste buds and their stem/progenitor cells
  • MMP7 inhibition of BMP7 induced renal tubular branching morphogenesis suggests a role in the pathogenesis of human renal dysplasia
  • key molecule regulated by F-spondin in cementoblast differentiation
  • HOXC6 play an important role in several cellular events through the regulation of its functional biological targets such as BMP7, FGFR2, and PDGFRA
  • UBE2O potentiated BMP7 signalling in a SMAD6-dependent manner
  • is an antifibrotic cytokine that antagonises TGFB1
  • SCUBE1 directly binds to BMP7 and its receptors, functioning as a BMP co-receptor to promote BMP7 signaling
  • cell & other
    activated by GLI and GLI3
    cleaved by subtilisin like convertases
    inhibited by by Drm (Gremlin), follistatin, and Noggin (associated to upregulation of BMP4 may play an integral role in the development of fracture nonunions)
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in breast cancer
    tumoral   amplification    
    in breast cancer
    tumoral     --over  
    in myelofibrosis
    tumoral     --low  
    in primary breast cancer is significantly associated with the formation of clinically overt bone metastases
  • to hypospadias
  • Variant & Polymorphism other
  • polymorphism increasing the risk of hypospadias
  • Candidate gene
    Therapy target
    . potential new therapeutic approach for the treatment of obesity (treatment with BMP7 or its molecular mimetic may activate brown fat differentiation, leading to an increase in energy expenditure, and thereby providing a new way to combat obesity
    . may represent a novel therapeutic molecule for repression of local and bone metastatic growth of breast cancer
    possible treatment for reversing end-stage renal disease
  • Bmp7-deficient mice exhibit substantially diminished Langerhans cell (LC) numbers, with the remaining cells appearing less dendritic