| basic FUNCTION
| putative protease, regulating myogenesis through dosage-dependent PAX3 expression in pre-myogenic cells |
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involved in bone formation (in osteogenic differentiation, not chondrogenic) |
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promoting chondrogenic differentition of multipotential mesenchymal cells |
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inducing placental growth factor in mesenchymal stem cells |
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important regulator of osteoblast differentiation, (regulation of Notch signaling genes during differentiation of osteoblast precursor cells) |
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necessary component of the signaling cascade that governs fracture repair |
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key mediator of bone development and repair |
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promoting tumor growth |
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plays a vital role in odontoblast function via diverse signal transduction systems |
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mediates DSPP gene expression and odontoblast differentiation via NF-Y signaling during tooth development |
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control CDKN1C expression and cell growth arrest/terminal differentiation in normal primary epidermal keratinocytes  |
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significantly induced latexin expression in RUNX2-deficient mesenchymal cells, during chondrocyte and osteoblast differentiation |
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induces Runx2-deficient cells to express markers related to osteoblast and chondroblast differentiation using a Runx2-independent pathway, but it failed to induce these cells to differentiate into bone-forming osteoblasts and mature chondrocytes |
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mediates embryonic cardiac contractility upstream of myocyte-specific enhancer factor 2A (MEF2A) |
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involved in the pathobiology of cartilaginous and osteogenic metaplasia observed in synovial chondromatosis |
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required for cardiac contractility and MEF2A expression can be activated by BMP2 signaling in neonatal cardiomyocytes |
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involved in the assembly of the cardiac contractile apparatus |
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BMP2 divergently regulates mRNA expression of various K(V) channel alpha-, beta-, and gamma-subunits and significantly increases whole cell K(V) currents |
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activating SOX9 (activation associated with chromatin remodeling and histone modification) |
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promotes motility and invasion of gastric cancer cells by activating PI-3 kinase/Akt pathway |
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both BMP2 and BMP4 can suppress the expression of DPYSL2 in primary cortical cells at the transcriptional level |
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morphogen that controls mesenchymal cell differentiation and behavior |
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regulates the osteogenic function of DLX5, at least in part, through PRKACA |
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regulate the function of DLX5 by post-translational modification through PRKACA, MAPK14 and possibly other kinases in addition to its regulation on DLX5 transcription |
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regulates the osteogenic function of Osterix (SP7), at least in part, through AKT1 |
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induces RUNX2 expression at both the transcriptional and post-transcriptional level |
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increases ER stress, which, in turn, leads to increased expression of RUNX2 |
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in coronary artery smooth muscle cell, increases oxidant stress and ER stress to increase RUNX2 expression and promote vascular smooth muscle cell calcification |
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BMP2-induced osteoblast differentiation mediates mild ER stress-activated ATF6 and directly regulates BGLAP expression |
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regulates osteoblast differentiation via RUNX2-dependent ATF6 expression and activation of ATF6 via ER stress-induced intramembrane proteolysis process |
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BMP2 mediates mild endoplasmic reticulum stress-activated ATF6 and directly regulates XBP1 splicing in the course of chondrogenesis |
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endogenous BMP2 expression in chondrocytes may play an essential role in cartilage callus maturation at an early stage of fracture healing |
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BMP2 and BMP7 both promoted odontogenic and osteogenic differentiation of tooth germ stem cells (hTGSCs) |
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important role of BMP2 in human craniofacial, skeletal, and cardiac development |
