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FLASH GENE
Symbol BLZF1 contributors: mct - updated : 04-02-2014
HGNC name basic leucine zipper nuclear factor 1 (JEM-1)
HGNC id 1065
Location 1q24.2      Physical location : 169.337.193 - 169.365.778
Synonym name
  • JEM-1short protein
  • Synonym symbol(s) JEM1, GOLGIN-45, JEM-1, JEM-1s, MGC22497
    DNA
    TYPE functioning gene
    STRUCTURE 28.59 kb     8 Exon(s)
    Genomic sequence alignment details
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status confirmed
    Map cen - D1S196 - D1S431 - D1S445 - D1S2658 - SELE - BLZF1 - D1S433 - qter
    Authors Gene Map (98)
    Physical map
    PC326 1q23.3 PC326 protein GCSH 16q24 glycine cleavage system protein H (aminomethyl carrier) GPR161 1q23.3 G protein-coupled receptor 161 MGC3794 1q23.2 putative MAPK activating protein RPL34P1 1q23-q24 ribosomal protein L34 pseudogene 1 LOC375035 1q23.3 hypothetical protein LOC375035 MGC12538 1q23.3 hypothetical protein MGC12538 TBX19 1q23-q24 T-box 19 LOC391131 1 similar to glutaminyl-tRNA synthase (glutamine-hydrolyzing)-like 1 XCL2 1q23-q25 chemokine (C motif) ligand 2 XCL1 1q23 chemokine (C motif) ligand 1 DPT 1q12-q23 dermatopontin MGC4473 1q23.3 hypothetical protein MGC4473 LOC391132 1 similar to ribosomal protein L29 ATP1B1 1q23.2-q23.3 ATPase, Na+/K+ transporting, beta 1 polypeptide NME7 1q24 non-metastatic cells 7, protein expressed in (nucleoside-diphosphate kinase) BLZF1 1q24-q25 basic leucine zipper nuclear factor 1 (JEM-1) LOC57821 1q24 hypothetical protein LOC57821 SLC19A2 1q23.2-q23.3 solute carrier family 19 (thiamine transporter), member 2 F5 1q23.2-q23.3 coagulation factor V (proaccelerin, labile factor) SELP 1q23.2-q41.2 selectin P (granule membrane protein 140kDa, antigen CD62) SELL 1q23.2-q23.3 selectin L (lymphocyte adhesion molecule 1) SELE 1q23.2-q23.1 selectin E (endothelial adhesion molecule 1) MGC9084 1q23.3 hypothetical protein MGC9084 FLJ10706 1q23.3 hypothetical protein FLJ10706 PACE-1 1q23.3 ezrin-binding partner PACE-1 KIFAP3 1q23.2 kinesin-associated protein 3 MRPS10P1 1q23.2 mitochondrial ribosomal protein S10 pseudogene 1 LOC149281 1q23.3 similar to AD-003 protein LOC388713 1 LOC388713 FLJ11752 1q23.3 NTKL-binding protein 1 PRRX1 1q23-1q25 paired related homeobox 1
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    8 - 2344 45 400 ubiquitous 1997 9129147
  • JEM1L
  • - polyA site 1300 23 174 cytoplasmic 1997 9129147
    extension exon 3 and P
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Reproductivefemale systemuteruscervix highly
     female systemplacenta  highly
    Respiratoryrespiratory tractlarynx  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a leucine repeat domain, interacting in the nucleus with AP1 (activator protein 1)
  • a PEST motif and several phosphorylation sites
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY regulatory , DNA associated , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,lumen
    intracellular,cytoplasm,organelle,Golgi
    intracellular,nucleus
    basic FUNCTION
  • basic leucine zipper protein nuclear transcription factor, involved in the transcription regulation from POLR2 promoter
  • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component with GORASP2 form a RAB2A effector complex on medial-Golgi essential for normal protein transport and Golgi structure
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • BLZF1 and CASC3 are further substrates targeted by tankyrase and RNF146 for degradation
  • with BLZF1 and ARHGEF28, LURAP1 bind MYO18A
  • cell & other
    REGULATION
    Other upregulated during retinoid-induced maturation of NB4-promyelocytic leukemia cells
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS