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FLASH GENE

Symbol

BLVRB

contributors: - updated : 05-06-2006

HGNC name	biliverdin reductase B (flavin reductase (NADPH))
HGNC id	1063

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	19q13.13-q13.2      Physical location : 40.953.690 - 40.971.725
Synonym name	flavin reductase (NADPH)
Synonym symbol(s)	BVRB, FLR, MGC117413
EC.number	1.3.1.24

DNA

TYPE	functioning gene
STRUCTURE	17.00 kb     5 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

status

provisional

RNA

TRANSCRIPTS	type	messenger

EXPRESSION

Type

widely

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive liver       predominantly   salivary gland       highly Endocrine parathyroid       highly Nervous brain         Reproductive female system breast mammary gland   highly Respiratory lung

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / Hematopoietic bone marrow       Epithelial secretory glandular endocrine

cells

System Cell Pubmed Species Stage Rna symbol Blood/Hematopoietic erthrocyte

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

fetal, pregnancy

Text

liver

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

a single substrate binding site, to which substrates and inhibitors bind primarily through hydrophobic interactions, explaining its broad specificity

mono polymer

monomer

HOMOLOGY

Homologene

FAMILY

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm

basic FUNCTION	flavin reductase (NADPH), catalyzing electron transfer from reduced pyridine nucleotides to flavins as well as methylene blue, pyrroloquinoline quinone, riboflavin, or methemoglobin
	possible role in protecting cells from oxidative damage or in regulating iron metabolism
	in the liver, converting biliverdin to bilirubin
	displaying an alpha/beta dinucleotide binding fold

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

porphyrin/heme

signaling

final step of heme pathway

a component

INTERACTION

DNA

RNA

small molecule	metal binding, cofactor, nucleotide,
	zinc Zn2+
	NADPH

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS