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FLASH GENE
Symbol BLVRA contributors: mct - updated : 05-04-2008
HGNC name biliverdin reductase A
HGNC id 1062
Location 7p14-cen      Physical location : 43.798.271 - 43.846.936
Synonym symbol(s) BLVR, BVR, BVRA
EC.number 1.3.1.24
DNA
TYPE functioning gene
STRUCTURE 48.00 kb     8 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status confirmed
Physical map
LOC393047 7 similar to olfactory receptor MOR261-1 BLVRA 7p14-cen biliverdin reductase A LOC393048 7 similar to Olfactory receptor 2A12 LOC393049 7 similar to seven transmembrane helix receptor LOC393050 7 similar to seven transmembrane helix receptor LOC393051 7 similar to seven transmembrane helix receptor LOC393052 7 similar to seven transmembrane helix receptor LOC393053 7 similar to seven transmembrane helix receptor MRPS24 7p14 mitochondrial ribosomal protein S24 LOC340310 7q35 similar to hypothetical protein MGC41943 FLJ43692 7q35 FLJ43692 protein URG4 7p13 up-regulated gene 4 LOC393054 7 similar to Olfactory receptor 2A1 LOC51619 7p13 ubiquitin-conjugating enzyme HBUCE1 LOC393055 7 hypothetical gene supported by BC016940 OR2A4 6q33-q35 olfactory receptor, family 2, subfamily A, member 4 STK17A 7p14-p12 serine/threonine kinase 17a (apoptosis-inducing) LOC392664 7 similar to RAS p21 protein activator 4; GTPase activating protein-like; Ca2+-promoted Ras inactivator; calcium-promoted Ras inactivator LOC393056 7 similar to Olfactory receptor 2A1 FLJ10803 7p13 hypothetical protein FLJ10803 WBSCR19 7q11.23 Williams Beuren syndrome chromosome region 19 LOC393057 7 hypothetical gene supported by BC016940 ARHGEF5 7q33-q35 Rho guanine nucleotide exchange factor (GEF) 5 LOC392893 7 similar to RasGAP-activating-like protein 2 (Calcium-promoted Ras inactivator) HIP-55 7p13 src homology 3 domain-containing protein HIP-55 LOC393058 7 similar to OG-2 homeodomain protein-like; similar to U65067 (PID:g1575526) PGAM2 7p13-p12 phosphoglycerate mutase 2 (muscle) POLM 7p13 polymerase (DNA directed), mu LOC393059 7 similar to peptidyl-Pro cis trans isomerase AEBP1 7p15.1 AE binding protein 1 TPK1 7q34 thiamin pyrophosphokinase 1 POLD2 7p15.1 polymerase (DNA directed), delta 2, regulatory subunit 50kDa BLVRA 7p14-cen biliverdin reductase A MYL7 7p21-p11.2 myosin, light polypeptide 7, regulatory GCK 7p14-p13 glucokinase (hexokinase 4, maturity onset diabetes of the young 2) YKT6 7p15.1 SNARE protein Ykt6 CAMK2B 7p13 calcium/calmodulin-dependent protein kinase (CaM kinase) II beta MRPS24 7p14 mitochondrial ribosomal protein S24 URG4 7p13 up-regulated gene 4 LOC51619 7p13 ubiquitin-conjugating enzyme HBUCE1 LOC389486 7 similar to RAS p21 protein activator 4; GTPase activating protein-like; Ca2+-promoted Ras inactivator; calcium-promoted Ras inactivator WBSCR19 7q11.23 Williams Beuren syndrome chromosome region 19 KIAA1068 7p13-p12 Williams Beuren syndrome chromosome region 19 LOC392023 7 similar to RasGAP-activating-like protein 2 (Calcium-promoted Ras inactivator) HIP-55 7p13 src homology 3 domain-containing protein HIP-55 PGAM2 7p13-p12 phosphoglycerate mutase 2 (muscle)
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
8 - 1094 - 296 - Franklin (2007)
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver    
 salivary gland   highly
Urinarykidney   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectivebone  highly
Muscularstriatumskeletal highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
CATEGORY enzyme
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm
basic FUNCTION
  • catalyze the conversion of biliverdin to bilirubin in the presence of NADPH or NADH
  • catalyzes reduction of the heme oxygenase activity product, biliverdin, to bilirubin
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism porphyrin/heme
    signaling
    final step of heme pathway
    a component
    INTERACTION
    DNA
    RNA
    small molecule cofactor, nucleotide,
  • NADH
  • NADPH
  • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS